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Beta Cell Biology Consortium

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 1, 2015. Consortium that aims to facilitate interdisciplinary collaborations to advance the understanding of pancreatic islet development and function, with the goal of developing innovative therapies to correct the loss of beta cell mass in diabetes, including cell reprogramming, regeneration and replacement. They are responsible for collaboratively generating the necessary reagents, mouse strains, antibodies, assays, protocols, technologies and validation assays that are beyond the scope of any single research effort. The scientific goals for the BCBC are to: * Use cues from pancreatic development to directly differentiate pancreatic beta cells and islets from stem / progenitor cells for use in cell-replacement therapies for diabetes, * Determine how to stimulate beta cell regeneration in the adult pancreas as a basis for improving beta cell mass in diabetic patients, * Determine how to reprogram progenitor / adult cells into pancreatic beta-cells both in-vitro and in-vivo as a mean for developing cell-replacement therapies for diabetes, and * Investigate the progression of human type-1 diabetes using patient-derived cells and tissues transplanted in humanized mouse models. Many of the BCBC investigator-initiated projects involve reagent-generating activities that will benefit the larger scientific community. The combination of programs and activities should accelerate the pace of major new discoveries and progress within the field of beta cell biology.

URL: http://www.betacell.org/

Resource ID: nlx_144143     Resource Type: Resource     Version: Latest Version

Keywords

pancreatic islet, mouse, beta cell, pancreas, pancreatic development, embryonic stem cell, cell line, genomics, antibody, adenovirus, functional genomics, mouse embryonic stem cell line, mouse strain, protocol, embryonic stem cell line, data sharing, data set, gene expression, gene, pancreatic islet development, pancreatic islet function, basic science, basic research, cell reprogramming, cell regeneration, cell replacement

Comment

Sample type: Cell line, Embryonic stem cell line Access: open; Copyrights - http://www.mgtaylor.com/ Reuse: closed; Copyrights - http://www.betacell.org/content/disclaimerterms/#terms Start date: 2002 Type: disciplinary Deposit: restricted: registration (info provided by re3data.org) Type: Academia Participant countries: U.S. Country started: U.S. Number of partners: 50 Start date: 2001

Listed By

One Mind Biospecimen Bank Listing, Biobank, re3data.org, Consortia-pedia

Availability

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 1, 2015. Information pertaining to 495 selected resources, judged to be the most scientifically-useful, has been converted into a static catalog. In addition, the metadata for these 495 resources have been transferred to dkNET in the form of RDF descriptors, and all genomics data have been deposited to either ArrayExpress or GEO.

Related Disease

Type 2 diabetes, Type 1 diabetes, Diabetes, Loss of beta cell mass

Related To

Karolinska Institutet; Stockholm; Sweden, University of California at Los Angeles; California; USA, Stanford University; California; USA, University of Massachusetts Medical School; Massachusetts; USA, Hebrew University Hadassah Medical School; Jerusalem; Israel, Philipps-University Marburg; Marburg; Germany, Imperial College London; London; United Kingdom, Childrens Hospital of Philadelphia - Research Institute; Pennsylvania; USA, Vanderbilt University Medical Center, Icahn School of Medicine at Mount Sinai; New York; USA, University of California at San Francisco; California; USA, Massachusetts Institute of Technology; Massachusetts; USA, Hadassah Medical Center; Jerusalem; Israel, DanStem, Oregon Health and Science University; Oregon; USA, Vanderbilt University; Tennessee; USA, University of Chicago; Illinois; USA, University of Massachusetts; Massachusetts; USA, University of Colorado Boulder; Colorado; USA, Vrije Universiteit Brussel; Brussels; Belgium, University of Geneva; Geneva; Switzerland, University of Pennsylvania Perelman School of Medicine; Pennsylvania; USA, Brigham and Womens Hospital, McEwen Centre for Regenerative Medicine, Seattle Childrens Research Institute; Washington; USA, Columbia University; New York; USA, Massachusetts General Hospital, University of Texas Southwestern Medical Center; Texas; USA, Hagedorn Research Institute; Gentofte; Denmark, Howard Hughes Medical Institute, Northwestern University; Illinois; USA, CAMRD, French National Center for Scientific Research, University of California at San Diego; California; USA, University of Pittsburgh; Pennsylvania; USA, University of Copenhagen; Copenhagen; Denmark, Jackson Laboratory, Max Planck Institute for Heart and Lung Research; Bad Nauheim; Germany, Cincinnati Childrens Hospital Medical Center, Indiana University; Indiana; USA, University of Toronto; Ontario; Canada, Harvard University; Massachusetts; USA, Harvard Medical School; Massachusetts; USA, Boston Childrens Hospital, Howard Hughes Medical Institute

Abbreviation

BCBC

Parent Organization

Species

mouse, non-human animal, human

Supercategory

Resource

Funding Information

NIDDK, DK-01-014, DK-01-17, DK-01-18, DK-09-011

Additional Resource Types

Consortium, Database, Data Repository, Biospecimen Repository, Cell Repository, Organism Supplier, Experimental Protocol, Antibody Supplier

Used By

NIF Data Federation, dkNET

Related Application

Research

Original Submitter

Anonymous

Version Status

Curated

Submitted On

12:00am March 5, 2012

Originated From

SciCrunch

Changes from Previous Version

  • Description was changed
  • Comment was changed
  • Availability was changed

Version 4

Created 4 days ago by Kristen Jensen

Version 3

Created 2 weeks ago by Christie Wang

Version 2

Created 2 weeks ago by Christie Wang

Version 1

Created 3 years ago by Anonymous