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A biopharmaceutical company engaged in the discovery and development of Nanobodies, a novel class of antibody-derived therapeutic proteins based on single-domain antibody fragments, for a range of serious life-threatening human diseases including inflammation, hematology, oncology and pulmonary disease. The Company has approximately 25 projects in the pipeline and seven Nanobodies in clinical development. The unique characteristics of Nanobodies and continuous innovation have allowed Ablynx, and its partners, to develop differentiated drug products such as both antagonistic and agonistic Nanobodies, bispecific Nanobodies, Nanobodies against challenging targets such as ion channels and GPCRs, Nanobodies that are administered through alternative routes of administration and Nanobodies half-lives which can be modulated from hours to days to weeks. To date, Ablynx has generated Nanobodies against more than 235 different disease targets and has characterized potent antagonists in vitro against 38 different targets. The Company and its collaborators have obtained positive in vivo efficacy data from animal studies in eight major therapeutic programs in five disease areas. Ablynx''s in-house lead programs in the clinic, ozoralizumab, caplacizumab, and ALX-0061 are in Phase II clinical development. Ablynx''s clinical development program ALX-0141 has recently completed Phase I trials. ALX-0141 has been developed to inhibit bone loss associated with post-menopausal osteoporosis, rheumatoid arthritis, cancer and certain drugs. Another Nanobody in clinical development is ATN-192 (formerly known as PF-05230905), and Phase I results are expected during the first half of 2012. Finally, in December 2011, a Phase I study with the first inhaled Nanobody, ALX-0171, was initiated. ALX-0171 has the potential to be a first-in-class therapeutic to treat s (RSV). In parallel with its internally developed products, Ablynx has ongoing research collaborations and significant partnerships with major pharmaceutical companies, including Boehringer Ingelheim, Merck Serono, and Novartis. Ablynx is building a diverse and broad portfolio of therapeutic Nanobodies through these collaborations. Ablynx has a strong and broad IP position and is the only company in the world with rights in the field of therapy and diagnosis under the granted US and European patents that describe the composition of matter of Nanobodies (the Hamers patents), representing a distinct and unique position in the complex field of antibody-derived therapeutics. Nanobody is a registered trademark of Ablynx NV.

URL: http://www.Ablynx.com

Resource ID: nif-0000-30052     Resource Type: Resource     Version: Latest Version


nanobody, protein, antibody fragment, human disease, oncology, hematology, tumor, blood, therapy, therapeutic, pharmaceutical, drug product, drug

Related Disease

Inflammation, Cancer, Pulmonary disease, Thrombosis, Alzheimer''s disease, Rheumatoid arthritis, Osteoporosis, Thrombotic thrombocytopenic purpura, Respiratory syncytial virus





Additional Resource Types

Reagent Manufacture

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Original Submitter


Version Status


Submitted On

12:00am October 19, 2010

Originated From


Changes from Previous Version

  • Description was changed
  • Additional Resource Types was changed
  • Related Disease was changed

Version 2

Created 2 months ago by Christie Wang

Version 1

Created 5 years ago by Anonymous