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3D surgical atlases of the murine head

3D interactive atlas of two mouse brains, 129S1/SvImJ and C57Bl/6J. The aim of this resource is to enhance comparative morphometric analyses and stereotactic surgical procedures in mice. These representations of the murine brain and skull, in conjunction with the resource''s development of a new, more dynamic master coordinate system, provide improved accuracy with respect to targeting CNS structures during surgery compared with previous systems. The interactive three-dimensional nature of these atlases also provide users with stereotactic information necessary to perform accurate off-axis surgical procedures, as is commonly required for experiments such as in vivo micro-electroporation. In addition, three-dimensional analysis of the brain and skull shape in C57Bl, 129Sv, CD1, and additional murine strains, suggests that a stereotactic coordinate system based upon the lambda and rostral confluence of the sinuses at the sagittal midline, provides improved accuracy compared with the traditional lambdabregma landmark system. These findings demonstrate the utility of developing highly accurate and robust three-dimensional representations of the murine brain and skull, in which experimental outputs can be directly compared using a unified coordinate system.

URL: http://phm.utoronto.ca/~jeffh/surgical.htm

Resource ID: nif-0000-10249     Resource Type: Resource     Version: Latest Version


129s1/svimj, anatomy, brain, c57bl/6j, central nervous system, digital atlas, imaging assay, in vivo, micro-electroporation, morphometric analysis, skull, sterotactic, transgenic, imaging


MRI / CT atlases

Funding Information

Canadian Institute for Health Research, Ontario Research Development Challenge, NARSAD Young Investigator award,

Additional Resource Types






Parent Organization

Original Submitter


Version Status


Submitted On

12:00am October 18, 2010

Originated From


Changes from Previous Version

  • Description was changed
  • Funding Information was changed
  • Additional Resource Types was changed

Version 2

Created 2 weeks ago by Christie Wang

Version 1

Created 5 years ago by Anonymous