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Temperature experience-regulated gene expression changes have been shown to underlie long-term adaptation of the response threshold of the AFD thermosensory neuron pair, and contribute to thermotaxis behavioral plasticity in C. elegans . We previously showed that the SRTX-1 GPCR is expressed primarily in AFD and is localized to their sensory endings. Here we find that SRTX-1 levels are regulated by the animal's temperature experience. However, loss or overexpression of srtx-1 does not affect thermotaxis behaviors or examined temperature-evoked calcium responses in AFD. Our observations suggest that SRTX-1 may modulate AFD responses and behavior under defined temperature conditions, or in response to specific environmental stimuli.
Pubmed ID: 39611104
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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 5,2022.Tool that predicts interactions between transcription factors and their regulated genes from binding motifs. Understanding vertebrate development requires unraveling the cis-regulatory architecture of gene regulation. PRISM provides accurate genome-wide computational predictions of transcription factor binding sites for the human and mouse genomes, and integrates the predictions with GREAT to provide functional biological context. Together, accurate computational binding site prediction and GREAT produce for each transcription factor: 1. putative binding sites, 2. putative target genes, 3. putative biological roles of the transcription factor, and 4. putative cis-regulatory elements through which the factor regulates each target in each functional role.
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