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Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development.

Amit Kumar | Margaret Lualdi | Jadranka Loncarek | Young-Wook Cho | Ji-Eun Lee | Kai Ge | Michael R Kuehn
Developmental dynamics : an official publication of the American Association of Anatomists | 2014

Human PAX-Interacting Protein 1 (PAXIP1)-associated glutamate rich protein 1 (PAGR1, also known as PA1) originally was discovered as part of a complex containing PAXIP1 and histone H3K4 methyltransferases MLL3 and MLL4, suggesting a role in epigenetic gene regulation. Further in vitro studies suggested additional functions in DNA damage repair and transcription. However, in vivo analysis of PAGR1 function has been lacking.

Pubmed ID: 24633704

Research resources used in this publication

None found

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Antibodies used in this publication

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Associated grants

  • Agency: Intramural NIH HHS, United States
    Id: Z99 CA999999
  • Agency: Intramural NIH HHS, United States
    Id: Z99 DK999999
  • Agency: Intramural NIH HHS, United States
    Id: ZIA BC010256-18
  • Agency: Intramural NIH HHS, United States
    Id: ZIA DK075003-10

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AxioVision Imaging System (tool)

RRID:SCR_002677

Digital image processing system where microscope settings and processing steps may be adjusted in single user interface. Can acquire images from variety of cameras. Includes software package for capturing, archiving and preparing images for publication. Allows users to visualize and present images in several dimensions. Functionality of imaging toolbox expands constantly with wide range of different modules that are tailored to specific applications or microscope accessories. This resource is duplicated by SCR_018376

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Aperio ImageScope (tool)

RRID:SCR_020993

Software tool for pathology slide viewing. Used for access to color digital slide images to which you can adjust magnification, pan and zoom, compare different stains, annotate areas of interest, perform image analysis, and more. Allows to view slide images taken by Leica biosystems scanner.

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