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http://dblab.duhs.duke.edu/modules/dblabs_topcat/index.php

TOPPCAT stands for T-One weighted Perfusion imaging Parameter CAlculation Toolkit. TOPPCAT creates quantitative maps of Ktrans (volume transfer constant between blood plasma and the extravascular extracellular space) and fPV (fractional plasma volume) from dynamic T1-weighted perfusion images. At the current time, analysis using the method of Patlak plots (most appropriate for first pass dynamic contrast-enhanced MR imaging) is supported. As a preliminary step for the parameter calculation, TOPPCAT also creates maps of T1 and S0 (equilibrium magnetization) from multi-flip angle T1-weighted SPGR (or FLASH) sequences.Daniel P. Barboriak, James R. MacFall, Anthony O. Padua,Gerald E. York, Benjamin L. Viglianti, and Mark W. Dewhirst. Standardized software for calculation of Ktrans and vp from dynamic T1-weighted MR images. Presented at the International Society for Magnetic Resonance in Medicine Workshop on MR in Drug Development: From Discovery to Clinical Therapeutic Trials, McLean VA, April 2004.

Proper citation: T-One weighted Perfusion imaging Parameter CAlculation Toolkit (RRID:SCR_007376) Copy   

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http://www.ebi.ac.uk/Tools/emboss/cpgplot/indexhtml

This portal allows for the detection of regions of genomic sequences that are rich in the CpG pattern is important because such regions are resistant to methylation and tend to be associated with genes which are frequently switched on. Regions rich in the CpG pattern are known as CpG islands. The function of the program cpgplot is to plot CpG rich areas, and cpgreport to report all CpG rich regions. The nuclear genomes of vertebrates are mosaics of isochores, very long stretches of DNA that are homogeneous in base composition and are compositionally correlated with the coding sequences that they embed. Isochores can be partitioned in a small number of families that cover a range of GC levels. Program isochore plots GC content over a sequence. Sponsors: This resource is supported by European Bioinformatics Institute. Keywords: Software, Plotting, Pattern, CpG, Gene, Function, Isochore, DNA, Genome, Homogeneous, Coding, Sequence, Family, Sequencing,

Proper citation: EMBOSS CpGPlot/CpGReport/Isochore (RRID:SCR_007254) Copy   

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https://bams1.org/

Knowledge management system designed to handle neurobiological information at different levels of organization of vertebrate nervous system. Database and repository for information about neural circuitry, storing and analyzing data concerned with nomenclature, taxonomy, axonal connections, and neuronal cell types. Handles data and metadata collated from original literature, or inserted by scientists that is associated to four levels of organization of vertebrate nervous system. Data about expressed molecules, neuron types and classes, brain regions, and networks of brain regions.

Proper citation: Brain Architecture Management System (RRID:SCR_007251) Copy   

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http://www.neurolens.org/NeuroLens/

An integrated environment for the analysis and visualization of functional neuroimages. It is intended to provide extremely fast and flexible image processing, via an intuitive user interface that encourages experimentation with analysis parameters and detailed inspection of both raw image data and processing results. All processing operations in NeuroLens are built around a Plugin architecture, making it easy to extend its functionality. NeuroLens runs on Apple computers based on the G4, G5, or Intel chipsets and running MacOSX 10.4 (Tiger) or later. It is available free for academic and non-profit research use. * Operating System: MacOS * Programming Language: Objective C * Supported Data Format: AFNI BRIK, ANALYZE, COR, DICOM, MGH/MGZ, MINC, Other Format

Proper citation: NeuroLens (RRID:SCR_007372) Copy   

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http://casp.sourceforge.net

CASP is a tool to image analysis in comet assay. CASP has been developed to work with either color, or gray-scale images of fluorescence-stained comets saved in TIF format. In its present version CASP does not control a video or CCD camera. Comets stained with silver (dark cells on white background) must be converted into negative images in order to be analysed correctly. An unlimited number of images can be marked, CASP will load them successively into a image view window (see screenshot). Only comets oriented from left (head) to right (tail) can be analysed correctly. The user can adjust various thresholds of sensitivity and save the adjustments for future use. A measurement frame is drawn on the screen and its size adjusted. The adjustments are frozen to prevent accidental modification. The frame is moved onto a cell and measurement is activated. An intensity profile shows up on a profile window together with selected result values (right window on figure 1) and the result can be saved. In addition to such parameter as head radius, tail length etc, the program calculates the tail moment (TM) and the Olive tail moment (OTM). If several cells are present on the same picture, the user can proceed with the measurement of another cell on the same picture or can load a new picture. The saved results can be visualized during the working session in a spreadsheet in view results window. When measurements are terminated, the results can be exported into a text file and imported into a commercial spreadsheet calculation program. CASP is optimized for a 600x800 resolution. Sponsors: This work has been supported by the University of Wroclaw. Keywords: Comet, Assay, Software, Laboratory, Camera, Negative, Cell, Analysis, Image,

Proper citation: CASPLab: Comet Assay Software Project Laboratory (RRID:SCR_007249) Copy   

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http://sourceforge.net/projects/fiswidgets/

A set of Java libraries for rapidly creating GUIs for software modules (C, C++, Fortan, PERL scripts, etc.), and graphically controlling process flow among them. This allows a GUI to be created for existing image processing and analysis routines, which provides: 1) graphic elements for setting parameters, arguments, etc. (i.e., text dialogs, file browsers, etc.); 2) links to web based documentation; 3) simple point-and-click interface for setting up a path for data flow from one module to another. The purpose of FisWidgets is to provide an integrated and user-friendly environment for using the disparate and growing array of image processing and analysis tools created by different laboratories.

Proper citation: FisWidgets (RRID:SCR_007367) Copy   

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http://cardiogenomica.altervista.org/CARDIOGENOMICS/CardioGenomics%20Homepage.htm

The primary goal of the CardioGenomics PGA is to begin to link genes to structure, function, dysfunction and structural abnormalities of the cardiovascular system caused by clinically relevant genetic and environmental stimuli. The principal biological theme to be pursued is how the transcriptional network of the cardiovascular system responds to genetic and environmental stresses to maintain normal function and structure, and how this network is altered in disease. This PGA will generate a high quality, comprehensive data set for the functional genomics of structural and functional adaptation of the cardiovascular system by integrating expression data from animal models and human tissue samples, mutation screening of candidate genes in patients, and DNA polymorphisms in a well characterized general population. Such a data set will serve as a benchmark for future basic, clinical, and pharmacogenomic studies. Training and education are also a key focus of the CardioGenomics PGA. In addition to ongoing journal clubs and seminars, the PGA will be sponsoring symposia at major conferences, and developing workshops related to the areas of focus of this PGA. Information regarding upcoming events can be found in the Events section of this site, and information about training and education opportunities sponsored by CardioGenomics can be found on the Teaching and Education page. The CardioGenomics project came to a close in 2005. This server, cardiogenomics.med.harvard.edu, remains online in order to continue to distribute data that was generated by investigators under the auspices of the CardioGenomics Program for Genomic Applications (PGA). :Sponsors: This resource is supported by The National Heart, Lung and Blood Institute (NHLBI) of the NIH., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: CardioGenomics (RRID:SCR_007248) Copy   

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http://www.mediacy.com/imageproplus

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 18,2023. Software package to capture, process, measure, analyze and share images and data.

Proper citation: Image Pro Plus (RRID:SCR_007369) Copy   

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http://www.bna.org.uk/

The British Neuroscience Association, formerly known as The Brain Research Association, was officially relaunched in 1997, continuing many of the traditions of the BRA but with a professional and revamped style. Membership has increased dramatically since this time, now standing at 2000, and the BNA has increasingly taken a leading role in major events, such as hosting the Second Forum of European Neuroscience in Brighton in June, 2000. The BNA is the largest body representing all aspects of neuroscience from ion channels to whole animal behaviour. The Aims and Objectives of the Association are as follows: 1. To promote on a multidisciplinary basis the study of the development structure and function of the nervous system in health and disease. 2. To promote the dissemination of information to all those interested in the neurosciences and related disciplines by means of lectures, discussions, meetings and reports from time to time obtained from such researchers. 3. To advise as far as possible on issues in neurosciences related to health and disease. 4. To endeavour to increase public awareness and understanding of neuroscience research in health and disease. 5. To assist in the training of neuroscientists and other professionals engaged in neuroscience teaching and research. The BNA achieves these aims as follows: 1. By hosting a national meeting biennially, by publishing the proceedings of that meeting and distributing them to the scientific community. 2. By organising a number of focussed ''One Day symposia'' during the year, contributing to training courses for young neuroscientists and organising public lectures and events . 3. By regularly distributing information by the BNA Newsletter or by the BNA News E-mail Alert facility that can inform members about other relevant events, publications and topical issues. 4. By encouraging attendance at its own national meeting and those to which it is affiliated by awarding bursaries to students and young postdoctoral workers, and facilitating participation in the Society for Neuroscience annual meeting by offering sponsored abstract forms. 5. By awarding graduate and undergraduate prizes, and special awards to senior neuroscientists and to lay people who have contributed significantly through their own charitable work to the success of our discipline. 6. By constantly negotiating special discount prices of relevant books and journals, and by offering free online access to the European Journal of Neuroscience.The BNA is the fastest growing learned society, now boasting more than 2000 members, a rise of more than 40% since its relaunch as the BNA in 1997 from the former Brain Research Association. In addition to discounted journals and books and other occasional ''special offers'', the benefits of membership now include the following: 1. Reduced registration fees (up to 50%) to the National Meeting, and FREE admission to many events throughout the year including ''One Day Symposia'' and The Christmas Symposium. 2. Regular mailing of BNA Bulletin and other relevant items. 3. Regular BNA and FENs Email Alert service. 4. Student prizes, and bursaries for attendance at BNA, FENS and IBRO meetings. 5. Free on-line access to European Journal of Neuroscience. 6. Concessionary (SFN membership rate) registration fees and sponsored abstract forms for Society for Neuroscience annual meeting. 7. Free advertising in the BNA Bulletin and on the BNA Website. 8. Free (automatic) membership of the Federation of European Neuroscience Societies (FENS), the International Brain Research Organisation (IBRO) and the Biosciences Federation (BSF). educational resource; jobs.

Proper citation: British Neuroscience Association (RRID:SCR_007402) Copy   

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http://www.autism-society.org/

ASA, the nations leading grassroots autism organization, exists to improve the lives of all affected by autism. We do this by increasing public awareness about the day-to-day issues faced by people on the spectrum, advocating for appropriate services for individuals across the lifespan, and providing the latest information regarding treatment, education, research and advocacy. :Founded in 1965 by Dr. Bernard Rimland, Dr. Ruth Sullivan and many other parents of children with autism, ASA is the leading source of trusted and reliable information about autism. Through its strong chapter network, ASA has spearheaded numerous pieces of state and local legislation, including the 2006 Combating Autism Act, the first federal autism-specific law. ASAs website is one of the most visited websites on autism in the world and its quarterly journal, Autism Advocate, has a broad national readership. ASA also hosts the most comprehensive national conference on autism, attended by 2000 people each year. Our information and referral team, our program staff, and our strong chapter presence serve thousands of families each year who are searching for help in their journey with autism. :ASAs national office is headquartered in Bethesda, Maryland. ASA is a member and chapter organization whos national Board of Directors is composed of democratically elected members and appointed members. We are proud to be one of the few organizations to have members with autism serving as active board directors. ASAs Panel of Professional Advisors sets the standards for our Options Policy that governs our practices, and we are proud to count the top professional experts in autism on our PPA. ASAs Panel of People on the Spectrum of Autism Advisors is a first-of-its-kind advisory panel comprised solely of individuals with autism, who help ASA staff create programs and services that will advocate for the rights of all people with autism to live fulfilling, interdependent lives. :Each year, people with autism, families and professionals volunteer thousands of hours to help ASA achieve its mission of serving all those affected by autism. To each and every one of you, thank you :

Proper citation: Autism Society of America (RRID:SCR_007401) Copy   

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http://ideas.repec.org/c/boc/bocode/s360702.html

COLELMS calculates LMS values, smoothed LMS, and growth reference centiles based in smoothed LMS values. df value is set to when calculating smoothed LMS values. You are responsible for setting an appropriate df for your data. This is version 0.2 of the software. Sponsors: This resource is supported by Boston College. Keywords: Software, LMS, Calculation, Growth, Data, Stata, Module,

Proper citation: COLELMS: Stata module to calculate Coles LMS values for growth data (RRID:SCR_007244) Copy   

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http://ncmir.ucsd.edu/downloads/fido.shtm

An interactive, graphic, fiducial marking software for placing, editing and tracking fiducial marks on images in a tomography tilt series. You can also use this tool to view the tilt series as well as crop it.

Proper citation: XFido (RRID:SCR_007365) Copy   

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http://www.salk.edu/labs/slesinger/index.php

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. This lab is investigating the molecular details of how potassium ion channels open and close (i.e. gating), the cellular regulation of potassium channels in nerve cells, and more recently, their role in drug addiction and mental disorders. There are currently two related areas of focus in the lab. One main area of research is investigating the G protein regulation of GIRK channels, utilizing structural, biochemical and electrophysiological strategies. The other area extends from the G protein regulation experiments to studies that examine the role of GIRK channels in the neural response to drugs of abuse, utilizing biochemical, electrophysiological and behavioral strategies.

Proper citation: Salk Institute for Biological Studies - Slesinger Lab (RRID:SCR_001850) Copy   

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http://cmb.gis.a-star.edu.sg/ChIPSeq/paperCCAT.htm

THIS RESOURCE IS OUT OF SERVICE, documented on April 5, 2017, A software package for the analysis of ChIP-seq data with negative control., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: CCAT (RRID:SCR_001843) Copy   

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http://www.genabel.org/packages/GenABEL

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. R software library for genome-wide association analysis for quantitative, binary and time-till-event traits.

Proper citation: GenABEL (RRID:SCR_001842) Copy   

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http://surfer.nmr.mgh.harvard.edu/

Open source software suite for processing and analyzing human brain MRI images. Used for reconstruction of brain cortical surface from structural MRI data, and overlay of functional MRI data onto reconstructed surface. Contains automatic structural imaging stream for processing cross sectional and longitudinal data. Provides anatomical analysis tools, including: representation of cortical surface between white and gray matter, representation of the pial surface, segmentation of white matter from rest of brain, skull stripping, B1 bias field correction, nonlinear registration of cortical surface of individual with stereotaxic atlas, labeling of regions of cortical surface, statistical analysis of group morphometry differences, and labeling of subcortical brain structures.Operating System: Linux, macOS.

Proper citation: FreeSurfer (RRID:SCR_001847) Copy   

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http://compbio.iupui.edu/group/6/pages/alteventfinder

Software tool for deriving data-driven alternative splicing (AS) events from RNA-seq data. It analyses the transcripts built by Cufflinks or Scripture and outputs AS event annotations which is compatible with MISO. It can be used for annotating novel AS events from a well-annotated species such as human. It can also be used for species of which known AS event annotation is not available. The current release (v0.1) supports skipped exon events only.

Proper citation: Alt Event Finder (RRID:SCR_001846) Copy   

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http://silac.org/

Stable isotope labeling with amino acids in cell culture (SILAC) is a simple and straightforward approach for in vivo incorporation of a label into proteins for mass spectrometry (MS)-based quantitative proteomics. SILAC relies on metabolic incorporation of a given "light" or "heavy" form of the amino acid into the proteins. The method relies on the incorporation of amino acids with substituted stable isotopic nuclei (e.g. deuterium, 13C, 15N). In an experiment, two cell populations are grown in culture media that are identical except that one of them contains a "light" and the other a "heavy" form of a particular amino acid (e.g. 12C and 13C labeled L-lysine, respectively). When the labeled analog of an amino acid is supplied to cells in culture instead of the natural amino acid, it is incorporated into all newly synthesized proteins. After a number of cell divisions, each instance of this particular amino acid will be replaced by its isotope labeled analog. Since there is hardly any chemical difference between the labeled amino acid and the natural amino acid isotopes, the cells behave exactly like the control cell population grown in the presence of normal amino acid. It is efficient and reproducible as the incorporation of the isotope label is 100%. SILAC Applications: - Differential expression of proteins and identification of disease biomarkers - Cell signaling dynamics - Analysis of yeast pheromone signaling pathway - Identification of methylation sites - Identification of protease substrates - Study of protein complexes/protein interactions - Analysis of signaling pathways and effect of pharmacological inhibitors - Subcellular proteomics Sponsors: Supported in part by an NIH Roadmap grant Technology Center for Networks & Pathways of Lysine Modification.

Proper citation: Stable Isotope Labeling with Amino Acids in Cell Culture (RRID:SCR_001873) Copy   

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http://blog.expressionplot.com/

Software package consisting of a default back end, which prepares raw sequencing or Affymetrix microarray data, and a web-based front end, which offers a biologically centered interface to browse, visualize, and compare different data sets.

Proper citation: ExpressionPlot (RRID:SCR_001904) Copy   

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https://urgi.versailles.inra.fr/Tools/S-Mart

Software toolbox that manages your RNA-Seq and ChIP-Seq data and also produces many different plots to visualize your data. It performs several tasks that are usually required during the analysis of mapped RNA-Seq and ChIP-Seq reads, including data selection and data visualization. It includes the selection (or the exclusion) of the data that overlaps with a reference set, clustering and comparative analysis. It also provides many ways to visualize data: size of the reads, density on the genome, distance with respect to a reference set, and the correlation of two data sets (with cloud plots). A computer science background is not required to run it through a graphical interface and it can be run on any personal computer, yielding results within an hour for most queries.

Proper citation: S-MART (RRID:SCR_001908) Copy   

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