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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
Provides preclinical drug discovery and development services to facilitate discovery of small molecules that have potential to become cancer therapeutics.Offers expertise in drug discovery and facilitates process of uncovering novel treatments for cancer. Services include target evaluation and assay development; small molecule library preparation, screening, and curation; high throughput screening enablement; plate imaging and transfers; assay identification, development and implementation; standard and customized assays (including live cell metabolic assays, cell death assays, clonogenic assays, and alphascreen); support for hit-to-lead pharmacology (including pharmacokinetics and ADME/T); data analytics for hit-picking; investigational new drug (IND) enablement; and full pipeline project management.Offers consultation, training, educational workshops and seminars.
Proper citation: University of Miami Sylvester Comprehensive Cancer Center Molecular Therapeutics Shared Resource Core Facility (RRID:SCR_022892) Copy
Provides expertise and analysis support for basic and translational research, clinical trials, and both interventional and non-interventional population-based studies. Offers support for data and large scale data analysis projects. Services include support for data analysis and interpretation; software access; algorithm and database development; support of scientific review, monitoring, and oversight of clinical and population science research protocols; consultation, training, educational workshops, lectures and seminars.Biostatistics services include support for statistical design of clinical trials, population studies, and laboratory experiments; sample size determination and justification; statistical analysis plans; statistical support for data and safety monitoring of clinical trials; data analysis and interpretation; prediction model development using machine learning techniques; and database design and data management. Bioinformatics services include project design for high-throughput genomics studies; support for next generation sequencing data analysis (including whole transcriptome profiling; targeted region gene expression and single-cell RNA-seq; epigenomics profiling such as ChIP-seq and ATAC-seq; and exome or whole genome sequencing analysis); pathway analysis; microbiome data analysis; functional metagenomics analysis; drug sensitivity and genomic association analysis; genomic data integration using public databases; integration analysis of genomic data across multiple platforms; genomic data visualization; and bioinformatics methods, analysis pipeline, software and algorithm development. BBSR services can be utilized for QA/QC, including quality assessment of sequencing data, sample outlier detection, batch effect determination, evaluation of spike-in control methods, randomized block design, and other strategies for data normalization. T
Proper citation: University of Miami Sylvester Comprehensive Cancer Center Biostatistics and Bioinformatics Shared Resource Core Facility (RRID:SCR_022890) Copy
https://www.cincinnatichildrens.org/research/cores/mmac
Provides solutions in areas of study design, bioinformatic processing of amplicon and shotgun metagenomic sequencing data, integration of metagenomic and clinical data structures, and statistical analyses of microbial community samples. MMAC works closely with Microbial Genomics and Metagenomics Laboratory to streamline workflows for metagenomic sequencing, bioinformatic processing, and statistical analysis of microbiome projects.
Proper citation: Cincinnati Children's Hospital Microbial Metagenomics Analysis Center Microbial Genomics and Metagenomics Core Facility (RRID:SCR_022649) Copy
https://cbc.arizona.edu/research/support-services/facilities/molecular-structures-core
Core enables researchers to determine structures and dynamics, or motions, of large biomolecules such as proteins and DNA to understand how they interact with each other and with small molecules such as drugs.
Proper citation: University of Arizona Molecular Structures Core Facility (RRID:SCR_022888) Copy
https://sites.google.com/view/epsilon-uarizona/home?authuser=0
Facility offers imaging spectroscopy. Equipped with Xray Photoemission Spectroscopy, Ultraviolet Photoemission Spectroscopy, Inverse Photoemission Spectroscopy, energy filtered Photoelectron Emission Microscopy, and spatially resolved Angle Resolved Photoemission Spectroscopy and spatially resolved Xray Photoemission Spectroscopy.
Proper citation: University of Arizona Electron Photoemission Spectroscopy and Imaging Laboratory for Observation at the Nanoscale Core Facility (RRID:SCR_022887) Copy
https://cbc.arizona.edu/research/support-services/facilities/x-ray-diffraction-facility
Facility for investigation of single crystal and powder/thin film samples by X-Ray diffraction techniques.
Proper citation: University of Arizona Xray Diffraction Core Facility (RRID:SCR_022886) Copy
https://www.vet.upenn.edu/research/core-resources-facilities/imaging-core
Core provides access to light microscope systems to perform widefield, confocal, 2-photon/multiphoton, second harmonic generation, total internal reflection (TIRF), and high content imaging.
Proper citation: University of Pennsylvania Penn Vet Imaging Core Facility (RRID:SCR_022764) Copy
Core for surface science, thin films studies, and nano scale characterization. Provides analytical and educational services to department and university on preparation, modification, and study of solid surfaces.
Proper citation: University of Arizona Laboratory for Electron Spectroscopy and Surface Analysis Core Facility (RRID:SCR_022885) Copy
https://www.med.upenn.edu/bbl/bbl-cnb.html
Core aims to facilitate research in cognitive neuroscience through use of Computerized Neurocognitive Battery and neuroimaging.CNB is comprised of series of tests that have been applied in neuroimaging studies and can be used either in scanner as part of functional neuroimaging study or outside scanner for measuring individual differences in performance. Tests measure accuracy and speed of performance in major domains of cognition, including executive control functions (abstraction, attention, working memory), episodic memory (verbal, facial, spatial), complex cognitive processing (language reasoning, nonverbal reasoning, spatial processing), social cognition (emotion identification, emotion intensity differentiation, age differentiation) and sensorimotor and motor speed.
Proper citation: University of Pennsylvania Perelman School of Medicine Neuroimaging and Cognitive Core Facility (RRID:SCR_022899) Copy
https://bauercore.fas.harvard.edu/
Helps to advance research efforts in life sciences that cannot readily be accomplished in the traditional academic laboratory because of need for expensive instrumentation or automation, scientific or organizational infrastructure, or multidisciplinary expertise. Provides expertise and hands-on training and use of instrumentation for nominal fee. Researchers can sign up to use instrumentation through on-line scheduling system and conduct their experiments independently.
Proper citation: Harvard University Bauer Core Facility (RRID:SCR_022656) Copy
https://www.cincinnatichildrens.org/research/cores/dna-sequencing-genotyping
Supports production and analysis of DNA and RNA related data. Provides DNA and RNA sequencing, Next Generation sequencing, DNA extraction and high and low throughput SNP genotyping.
Proper citation: Cincinnati Children's Hospital DNA Sequencing and Genotyping Core Facility (RRID:SCR_022630) Copy
Supports development, scale -up and processing of innovative cell based therapies for clinical studies.
Proper citation: Cincinnati Children's Hospital Cell Manipulation Laboratory Core Facility (RRID:SCR_022627) Copy
https://www.cincinnatichildrens.org/research/cores/dmac
Centralized resource for clinical research data management, programming for clinical research databases, and statistical analysis.
Proper citation: Cincinnati Children's Hospital Data Management and Analysis Center Core Facility (RRID:SCR_022625) Copy
https://www.cincinnatichildrens.org/research/cores/mouse-core
Offers services for researchers exploring cancer systems through animal models. Provides animals from specific inbred mouse strains primarily used in cancer and hematopoietic research, offers cell transplant, harvest and irradiation services and can handle animal cancer model systems involving xenotransplant procedures.
Proper citation: Cincinnati Children's Hospital Comprehensive Mouse and Cancer Core Facility (RRID:SCR_022624) Copy
Supplies mononuclear cells, stem cells or other enriched cell populations. Provides stem cells and other tissue samples from normal donor or patient populations such as disease specific repositories or specific research studies requiring sample processing. Samples are provided fresh or cryopreserved according to availability, unprocessed or with further lab processing.Common processing techniques include PBMC isolation,Serum and plasma isolation,Separation of marker specific populations,Flow cytometric characterization of samples,Interferon gamma EliSpot.Additional services may be available upon request
Proper citation: Cincinnati Children's Hospital Cell Processing Core Facility (RRID:SCR_022623) Copy
Provides microscopes and imaging stations. Expert staff offers guide to non-expert users. Facility offers imaging expertise in Electron Microscopy, Optical Microscopy, In Vivo Imaging, and Histology.
Proper citation: University of Notre Dame Integrated Imaging Core Facility (RRID:SCR_022743) Copy
https://www.cincinnatichildrens.org/research/cores/animal
Offers behavioral phenotyping of rodent models as well as characterizing nervous system function in mouse and rat models through behavioral assays.
Proper citation: Cincinnati Children's Hospital Animal Behavior Core Facility (RRID:SCR_022621) Copy
http://www.ohsu.edu/xd/research/research-cores/small-animal-research-imaging-core/
Provides in vivo imaging technology to evaluate anatomy, tissue function, cellular and molecular phenotype, blood/fluid flow, metabolism and to assess pharmacokinetics and stem cell function in small animal models.Offers spatial resolution, temporal resolution, tissue differentiation, sensitivity for contrast agent, and performance of contrast agents. Services include MicroPET/SPECT/CT imaging,Ultra-high frequency small animal ultrasound imaging,Biophotonics imaging.
Proper citation: Oregon Health and Science University Small Animal Research Imaging Core Facility (RRID:SCR_022742) Copy
https://ncdiabetesresearch.org/acsmc
Core to leverage data, patient populations and investigators at each NCDRC institution, including accessing expertise and resources of regional Clinical and Translational Science Institute hubs (Duke, UNC, and Wake Forest). Research navigators in ACSMC provides input and navigation of clinical research resources available to diabetes investigators based on extensive experience in diabetes specific studies and methodology and deep knowledge of NCDRC resources available at each institution.
Proper citation: North Carolina Diabetes Research Center Advanced Clinical Study Methods Core Facility (RRID:SCR_022908) Copy
Provides diabetes researchers at University of Colorado with access to microscopy and mass cytometry systems. Provides expertise and training to use equipment effectively for diabetes related tissues; expertise and validated diabetes related resources to prepare samples appropriately; guidance to design experiments; resources to analyze data; assistance with data interpretation.
Proper citation: University of Colorado Anschutz Medical Campus Diabetes Research Center Cell and Tissue Analysis Core Facility (RRID:SCR_022906) Copy
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