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https://medschool.cuanschutz.edu/corefacilities/x-ray-crystallography
Core performs all aspects of structure determination of large biomolecules such as proteins and nucleic acids including macromolecular crystallization, crystal screening, molecular structure and model building.
Proper citation: University of Colorado Anschutz Medical Campus Cancer Center Structural Biology Shared Resource X Ray Crystallography Core Facility (RRID:SCR_021998) Copy
Molecular Pathology Section offers clinical grade sample processing and molecular testing for research cases.All services are performed in CLIA certified environment and all molecular assays are accompanied by full data analysis including bioinformatics analysis for NGS data.
Proper citation: University of Colorado Anschutz Medical Campus Cancer Center Pathology Shared Resource Molecular Pathology Core Facility (RRID:SCR_021995) Copy
Core specializes in targeted irradiation of small animals for use in preclinical trials of radiation therapy. Through use of XRAD-SmART Irradiator, core can use x-ray fluoroscopy and on board CBCT to accurately irradiate small lesion areas while protecting normal tissue. Provides experiment design, data analysis, and dosimetry calculations, as well as longitudinal acquisition of CBCT for temporal assessment of tumor growth kinetics.
Proper citation: University of Colorado Anschutz Medical Campus Cancer Center Small Animal Image Guided Radiation Therapy Core Facility (RRID:SCR_021996) Copy
https://www.biomedicas.unam.mx/servicios/unidad-de-microscopia/
Core is specialized in stereology techniques, live cell imaging, CLSM (confocal microscopy), and STORM. Provided instruments include CONFOCAL microscopes Zeiss LSM 5 Pascal, Olympus BX51-WI,Olympus IX71 inverted microscope, Nikon Labophot-2 microscope,Nikon Optiphot 2 microscope.
Proper citation: National Autonomous University of Mexico Microscopy Core Facility (RRID:SCR_022204) Copy
Core facilitates access, generation, and usage of novel in vitro mouse and human organoid systems to promote innovative basic and translational research and disease modeling. Provides expertise in genome editing technologies for targeted knock outs, point mutations, and reporter generation in organoid systems. Provides many specialized medias and reagents to support most common organoid culture systems.
Proper citation: University of Colorado Anschutz Medical Campus Cancer Center Organoid and Tissue Modeling Shared Resource Core Facility (RRID:SCR_021993) Copy
Core produces mice and rats for biomedical research. Provides services for customers are researchers from Unicamp and other Institutions from Brazil.
Proper citation: State University of Campinas Multidisciplinary Center for Biological Investigantion on Laboratory Animals Science Core Facility (RRID:SCR_022203) Copy
https://vtpb.tamu.edu/flow-cytometry/
Provides flow cytometry experimental design, data collection, data analysis and cell sorting services; training for flow cytometers, imaging flow cytometer, and data analysis using IDEAS and FlowJo software;staff assisted flow cytometry and imaging flow cytometry data acquisition, cell sorting, and data analysis, experimental design and consultation services. FCF currently has Beckman Coulter Moflo Astrios cell sorter, Luminex/Amnis Image Stream X Mark II, Luminex/Amnis Cell Stream, and Becton Dickinson Accuri C6 flow cytometer. Astrios cell sorter is housed in ClassII BSC and has 3 lasers (405nm, 488nm, 642nm) and 11 detectors and can sort up to 6 populations simultaneously. Image Stream X Mark II is equipped with 20x, 40x, 60x objectives, 4 lasers (405nm, 488nm, 561nm, 642nm), 10 detection channels, EV mode for small particle detection, and an autosampler.Cell Stream is equipped with 3 lasers (405nm, 488nm, 642nm), 13 detection channels, EV mode for small particle detection, and autosampler. Accuri C6 is equipped with 2 lasers (488nm, 642nm), and 4 detection channels.
Proper citation: Texas A and M University College of Veterinary Medicine and Biomedical Sciences Flow Cytometry Core Facility (RRID:SCR_022169) Copy
https://genetics.med.upenn.edu/cores/cell-center-services/
Facility provides basic cell culture training and services in various cell culture and related procedures e.g. Mycoplasma and Endotoxin testing. Services include cell culture at various scales, expansion of primary cells, seed cell cultures from on site cell bank, cell storage; large scale growth of hybridoma and other cell lines followed by antibody purification by protein G column or recombinant protein production; EBV induced transformation of lymphocytes.Offers hybridoma generation by cell fusion and screening and, transfection of mammalian cells. Facility prepares specialized cell culture media, Drosophila media and, various tissue culture and molecular biological reagents.
Proper citation: University of Pennsylvania Perelman School of Medicine Cell Center Services Core Facility (RRID:SCR_022391) Copy
https://www.itmat.upenn.edu/cnsc/
Provides expertise in medicinal chemistry, metal chelate chemistry, polymer synthesis, nanoparticle production and surface functionalization, and site-specific antibody labeling. Our chemists provide custom, problem specific support for researchers in medical, chemical, and materials science fields. Specific services include consultation and assistance with the design of chemical/medicinal compounds, in house synthesis of chemical/medicinal compounds, custom nanoparticle design and synthesis, custom nanoparticle surface functionalization, polymer and dendrimer synthesis, and site specific antibody labeling.
Proper citation: University of Pennsylvania Perelman School of Medicine Chemical and Nanoparticle Synthesis Core Facility (RRID:SCR_022390) Copy
https://www.med.upenn.edu/cbica/
Offers development and application of advanced computational and analytical techniques that quantify morphology and function from biomedical images, as well as on relating imaging phenotypes to genetic and molecular characterizations, and on integrating this information into diagnostic and predictive tools in era of personalized medicine. Computational methods can contribute significantly to automated, reproducible and quantitative interpretations of biomedical images. Translates advanced computational and analytical imaging methods to clinic, by providing forum in which interactions between researchers and clinicians facilitate bidirectional flow of ideas, algorithms and data between laboratory and clinic.
Proper citation: University of Pennsylvania Perelman School of Medicine Center for Biomedical Image Computing and Analytics Core Facility (RRID:SCR_022397) Copy
https://www.med.upenn.edu/CAMIPM/
Core dedicated to development and application of innovative, novel magnetic resonance and optical imaging techniques. Provides research and computing resources for projects with focus on developing instrumentation, methodologies, and data analysis techniques for quantitative assessment of functional, structural, and metabolic parameters in humans with use of multinuclear magnetic resonance, novel spectral, perfusion, functional, and optical imaging techniques.
Proper citation: University of Pennsylvania Perelman School of Medicine Center for Advanced Metabolic Imaging in Precision Medicine Core Facility (RRID:SCR_022396) Copy
Provides infrastructure support for research on human cognition, perception, affect, disordered cognition, and extension to preclinical models. By consolidating methodological expertise in these domain areas as services, center seeks to facilitate cutting edge research using largely shared set of methods and tools for elucidating brain behavior relationships in health and disease.
Proper citation: University of Pennsylvania Perelman School of Medicine Brain Science Service Center Core Facility (RRID:SCR_022394) Copy
https://www.med.upenn.edu/idom/drc/cores/rodent.html
Core (RMPC, formerly MPPMC) is metabolic core. Offers technology and phenotyping services to allow investigators to study metabolism in pre-clinical rodent models. Services include measurements of body composition (fat and lean mass) using NMR and DEXA, energy balance (food intake, locomotor activity, energy expenditure) using indirect calorimetry in either Columbus Instruments CLAMS system or Sable Systems Promethion System (with optional gas analyzer), and other in vivo metabolic phenotyping services (glucose clamps, insulin and glucose tolerance tests, telemetric monitoring of blood glucose or blood pressure, bomb calorimetry).
Proper citation: University of Pennsylvania Perelman School of Medicine Rodent Metabolic Phenotyping Core Facility (RRID:SCR_022427) Copy
https://www.med.upenn.edu/ipsccore/
Provides resources for disseminating human pluripotent stem cell technology within UPenn and surrounding research communities. �Our services include derivation of patient specific iPSCs, genome engineering of stem cell lines using CRISPR/Cas9 technology, and lineage specific differentiation of iPSCs/hESCs in 2D and 3D organoid culture.�Core has large collection of patient derived iPSC lines and cell lines of gastrointestinal tract (esophageal, pancreatic and intestinal) available to users.�Committed to training investigators in stem cell culture techniques and providing quality tested stem cell reagents to users.
Proper citation: University of Pennsylvania Perelman School of Medicine Induced Pluripotent Stem Cell Core Facility (RRID:SCR_022426) Copy
https://www.biotech.cornell.edu/core-facilities-brc/facilities/genomics-innovation-hub
Core complements services provided by BRC Genomics Facility.Working on collaborative model, protocol and method development by early adopters pave the way for larger scale production services.
Proper citation: Cornell University BRC Genomics Innovation Hub Core Facility (RRID:SCR_022547) Copy
https://www.med.upenn.edu/ris/
Shared resource machine shop serving various University of Pennsylvania Schools and Departments. Assists researchers to design and construct both laboratory and clinical instruments.
Proper citation: University of Pennsylvania Perelman School of Medicine Research Instrumentation Shop Core Facility (RRID:SCR_022424) Copy
https://www.dental.upenn.edu/research/core-facilities/
Provides Becton Dickinson LSR II flow cytometer equipped with four lasers.Blue laser can be used to detect forward and side scatter and 4 colors (eg., FITC/Alexa 488, PE, PerCP-CY55, PE-CY7), red laser can be used to detect 2 colors (e.g., APC and APC-CY7), violet laser can be used to detect 2 colors (e.g., Pacific blue, Am cyan) and a UV laser which can also be used to detect 2 colors (e.g., INDO1 blue, Indo1-violet/DAPI). The instrument is located in Room 330 in the Levy Building (240 South 40th Street).
Proper citation: University of Pennsylvania Penn Dental Medicine Flow Cytometry Core Facility (RRID:SCR_022443) Copy
https://www.vet.upenn.edu/research/core-resources-facilities/referral-center-for-animal-models
Core mission is to discover, create, characterize, treat, and share naturally occurring hereditary disorders in dogs and cats that are orthologous to those found in human patients.�Provides expertise in discovering, characterizing, and developing therapies for genetic disease in dogs and cats, which serve as models of same diseases that occur in children.�Specializes in molecular discovery of mutations, clinical phenotyping, biochemical and histological characterization, development of therapies which are translatable to human patients and preclinical trials in animal models of human disease.�
Proper citation: University of Pennsylvania Penn Vet Referral Center for Animal Models of Human Genetic Disease Core Facility (RRID:SCR_022440) Copy
Offers consultation and laboratory services for high-throughput sequencing (HTS) experiments, with particular expertise and interest in microbiome/metagenome and RNA-seq applications. Provides instrumentation, including Illumina NextSeq 2000 and single cell platforms from 10X genomics and 1CellBio. Offers full service options, as well as hands on instruction for trainees who want to learn best practices for wet lab aspects of genomics experiments. Offers consultation services for all phases of HTS studies, from study design to bioinformatics analysis.
Proper citation: University of Pennsylvania Penn Vet Center for Host Microbial Interactions Core Facility (RRID:SCR_022434) Copy
https://www.med.upenn.edu/cfar/virus-reservoirs.html
Facility provides comprehensive viral and molecular support in area of basic, translational and clinical HIV research, consultation, training, and mentoring.Is available to develop customized viral and molecular support services as needed. Offers deep sequencing support and single genome amplification services.
Proper citation: University of Pennsylvania Perelman School of Medicine Center for AIDS Research Virus and Reservoirs Core Facility (RRID:SCR_022403) Copy
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