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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
Mediation Analysis of Causality under Confounding
 
Resource Report
Resource Website
Mediation Analysis of Causality under Confounding (RRID:SCR_017442) MACC software application, software resource, data analysis software, data processing software Software package to perform causal mediation analysis under confounding or correlated errors. Includes single level mediation model, two level and three level mediation model for data with hierarchical structures. Under two or three level mediation model, correlation parameter is identifiable and is estimated based on hierarchical likelihood, marginal likelihood or two stage method. Casual, mediation, analysis, confounding, correlated, error, data, hierarchical, structure, parameter, BRAIN Initiative is recommended by: BRAIN Initiative
is listed by: CRAN
NIBIB EB022911 Free, Available for downloads, Freely available SCR_017442 Mediation Analysis of Causality under Confounding, macc 2026-07-28 09:44:34 0
ReproNim/containers
 
Resource Report
Resource Website
1+ mentions
ReproNim/containers (RRID:SCR_018467) narrative resource, knowledge environment resource, data or information resource, software resource, workflow, software toolkit, portal, training material Software containerized environments for reproducible neuroimaging. Part of ReproNim - Center for Reproducible Neuroimaging Computation. DataLad dataset with collection of popular computational tools provided within ready to use containerized environments. Containerized environment, reproducible neuroimaging, ReproNim, neuroimaging, dataset, DataLad, imaging, data is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC) NIBIB P41 EB019936;
NSF 1429999;
German Federal Ministry of Education and Research
Free, Freely available https://github.com/ReproNim/containers SCR_018467 2026-07-28 09:44:57 1
BpForms
 
Resource Report
Resource Website
BpForms (RRID:SCR_018653) software toolkit, software resource, data access protocol, web service Software toolkit for unambiguously describing molecular structure of DNA, RNA, and proteins, including non-canonical monomeric forms, crosslinks, nicks, and circular topologies. Aims to help epigenomics, transcriptomics, proteomics, systems biology, and synthetic biology researchers share and integrate information about DNA modification, post-transcriptional modification, post-translational modification, expanded genetic codes, and synthetic parts. Molecular structure description, DNA, RNA, protein, modification, epigenetics, transcriptomics, post transcriptional modification, post translational modification, bio.tools uses: BcForms
is used by: ObjTables
is used by: Datanator
is listed by: Debian
is listed by: bio.tools
is related to: BcForms
is related to: ObjTables
NIBIB P41 EB023912;
NSF 1649014;
NIGMS R35 GM119771
PMID:32423472 Free, Freely available biotools:bpforms https://bio.tools/bpforms SCR_018653 2026-07-28 09:44:47 0
ObjTables
 
Resource Report
Resource Website
ObjTables (RRID:SCR_018652) software application, software resource, data management software, data processing software, software toolkit Software toolkit for creating reusable datasets that are both human and machine readable, combining spreadsheets with schemas including classes, their attributes, type of each attribute, and possible relationships between instances of classes.Consists of format for describing schemas for spreadsheets, numerous data types for science, syntax for indicating class and attribute represented by each table and column in workbook, and software for using schemas to rigorously validate, merge, split, compare, and revision datasets. Used for supplementary materials of journal article, as well as for emerging domains which need to quickly build new formats for new types of data and associated software with minimal effort. Creating reusable dataset, combining spreadsheet with schema, spreadsheet, table, supplementary material, schema, object relational map, validation, bio.tools uses: BpForms
uses: BcForms
is listed by: bio.tools
is listed by: Debian
is related to: BpForms
NIBIB P41 EB023912;
NSF 1649014;
NIGMS R35 GM119771
Free, Freely available biotools:objtables https://bio.tools/objtables SCR_018652 2026-07-28 09:44:43 0
datasets.datalad.org
 
Resource Report
Resource Website
1+ mentions
datasets.datalad.org (RRID:SCR_019089) service resource, data set, data or information resource, data repository, storage service resource DataLad data distribution. Super dataset collating DataLad datasets from various sources including OpenNeuro, CRCNS, etc., to provide unified access to over 200TB of neural data. Version control system, data distribution, super dataset, DataLad dataset, neural data is related to: DataLad NSF 1429999;
NSF 1912266;
NIBIB P41 EB019936
Free, Freely available https://www.datalad.org/datasets.html SCR_019089 2026-07-28 09:44:51 8
NSR Physiome Project
 
Resource Report
Resource Website
1+ mentions
NSR Physiome Project (RRID:SCR_007379) NSR Physiome Project software application, training resource, data or information resource, software resource, simulation software, professional program, topical portal, portal Database of physiological, pharmacological, and pathological information on humans and other organisms and integration through computational modeling. Models include everything from diagrammatic schema, suggesting relationships among elements composing a system, to fully quantitative, computational models describing the behavior of physiological systems and an organism''s response to environmental change. Each mathematical model is an internally self-consistent summary of available information, and thereby defines a working hypothesis about how a system operates. Predictions from such models are subject to test, with new results leading to new models.BR /> A Tool developed for the NSR Physiome project is JSim, an open source, free software. JSim is a Java-based simulation system for building quantitative numeric models and analyzing them with respect to experimental reference data. JSim''s primary focus is in physiology and biomedicine, however its computational engine is quite general and applicable to a wide range of scientific domains. JSim models may intermix ODEs, PDEs, implicit equations, integrals, summations, discrete events and procedural code as appropriate. JSim''s model compiler can automatically insert conversion factors for compatible physical units as well as detect and reject unit unbalanced equations. JSim also imports the SBML and CellML model archival formats. All JSim models are open source. Goals of the Physiome Project: - To develop and database observations of physiological phenomenon and interpret these in terms of mechanism (a fundamentally reductionist goal). - To integrate experimental information into quantitative descriptions of the functioning of humans and other organisms (modern integrative biology glued together via modeling). - To disseminate experimental data and integrative models for teaching and research. - To foster collaboration amongst investigators worldwide, to speed up the discovery of how biological systems work. - To determine the most effective targets (molecules or systems) for therapy, either pharmaceutic or genomic. - To provide information for the design of tissue-engineered, biocompatible implants. physiome, computational modeling, cell, organ, organism, human, model, physiological, pharmacological, pathological, model repository, sbml, cellml, biophysics, biochemistry, database, proteome, jsim simulation analysis system, data analysis tool, parameter optimization tool, integrating biological system has parent organization: University of Washington; Seattle; USA NSF BE08407;
NHLBI T15 HL88516-01;
NSF BES-0506477;
NHLBI R01HL073598;
NIBIB R01EB001973
nif-0000-00532 SCR_007379 National Simulation Resource Physiome Project 2026-07-28 09:41:45 3
ezBIDS
 
Resource Report
Resource Website
ezBIDS (RRID:SCR_025563) web application, software resource Web-based BIDS conversion tool to convert neuroimaging data and associated metadata to BIDS standard. Guided standardization of neuroimaging data interoperable with major data archives and platforms. Guided standardization, neuroimaging data, Brain Imaging Data Structure, BIDS conversion tool, convert neuroimaging data, associated metadata, interoperable, BIDS standard, NINDS UM1NS132207;
BRAIN CONNECTS ;
NIBIB R01EB029272;
NIBIB R01EB030896;
NSF ;
Kavli Foundation ;
Wellcome Trust ;
NIMH R01MH133701;
Spanish Government
PMID:38332144 Free, Freely available https://brainlife.io/ezbids/, SCR_025563 ez Brain Imaging Data Structure 2026-07-27 09:37:26 0
BrainInfo
 
Resource Report
Resource Website
10+ mentions
BrainInfo (RRID:SCR_003142) narrative resource, data or information resource, database, standard specification, atlas, topical portal, portal Portal to neuroanatomical information on the Web that helps you identify structures in the brain and provides a variety of information about each structure by porting you to the best of 1500 web pages at 100 other neuroscience sites. BrainInfo consists of three basic components: NeuroNames, a developing database of definitions of neuroanatomic structures in four species, their most common acronyms and their names in eight languages; NeuroMaps, a digital atlas system based on 3-D canonical stereotaxic atlases of rhesus macaque and mouse brains and programs that enable one to map data to standard surface and cross-sectional views of the brains for presentation and publication; and the NeuroMaps precursor: Template Atlas of the Primate Brain, a 2-D stereotaxic atlas of the longtailed (fascicularis) macaque brain that shows the locations of some 250 architectonic areas of macaque cortex. The NeuroMaps atlases will soon include a number of overlays showing the locations of cortical areas and other neuroscientific data in the standard frameworks of the macaque and mouse atlases. Viewers are encouraged to use NeuroNames as a stable source of unique standard terms and acronyms for brain structures in publications, illustrations and indexing systems; to use templates extracted from the NeuroMaps macaque and mouse brain atlases for presenting neuroscientific information in image format; and to use the Template Atlas for warping to MRIs or PET scans of the macaque brain to estimate the stereotaxic locations of structures. brain, neuroanatomy is used by: NIF Data Federation
is listed by: Biositemaps
is related to: INIA19 Primate Brain Atlas
has parent organization: University of Washington; Seattle; USA
has parent organization: University of California at San Diego; California; USA
The Human Brain Project ;
NIBIB ;
NLM LM/OD-06243;
NIH Office of the Director LM/OD-06243;
NIMH MHO69259;
NCRR RR-00166
PMID:21789500
PMID:21163300
PMID:18368361
PMID:15055392
Free, Freely available nif-0000-00019 SCR_003142 Brain Info 2026-07-28 09:40:38 16
Reproducible Brain Charts
 
Resource Report
Resource Website
Reproducible Brain Charts (RRID:SCR_027837) data or information resource, data set Open data resource for mapping brain development and its associations with mental health. Integrates data from 5 large studies of brain development in youth from three continents (N = 6,346). Bifactor models were used to create harmonized psychiatric phenotypes, capturing major dimensions of psychopathology. Neuroimaging data were carefully curated and processed using consistent pipelines in a reproducible manner. Neuroimaging data, curated data, data resource, mapping brain development, mental health, NIMH R01MH120482;
NIMH R37MH125829;
NIBIB R01EB022573;
NIMH R01MH112847;
NIMH R01MH113550;
NIMH RF1MH121867;
NIMH R01MH123550;
NINDS U24NS130411;
NIMH P50MH109429;
NIMH R01MH123440;
NIMH K08MH079364
PMID:40987284 Free, Freely available SCR_027837 2026-07-27 09:37:59 0
Farsight Toolkit
 
Resource Report
Resource Website
1+ mentions
Farsight Toolkit (RRID:SCR_001728) FARSIGHT software application, software toolkit, software resource, data processing software, image processing software, image analysis software THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 23, 2022. A collection of software modules for image data handling, pre-processing, segmentation, inspection, editing, post-processing, and secondary analysis. These modules can be scripted to accomplish a variety of automated image analysis tasks. All of the modules are written in accordance with software practices of the Insight Toolkit Community. Importantly, all modules are accessible through the Python scripting language which allows users to create scripts to accomplish sophisticated associative image analysis tasks over multi-dimensional microscopy image data. This language works on most computing platforms, providing a high degree of platform independence. Another important design principle is the use of standardized XML file formats for data interchange between modules. editing, 2d, 3d, algorithm, analysis, bio-format, computational, data, graphical, inspection, metadata, microscopy, morphological, morphology, pixel, processing, segmentation, taxonomy, image has parent organization: University of Houston; Texas; USA NIBIB R01-EB005157;
NSF EEC-9986821;
NIBIB R01EB005157
PMID:24808857 THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-10227 SCR_001728 FARSIGHTWiki 2026-07-28 09:40:15 2
Atlas3D
 
Resource Report
Resource Website
10+ mentions
Atlas3D (RRID:SCR_001808) software application, data or information resource, atlas, software resource, data visualization software, data processing software A multi-platform visualization tool which allows import and visualization of 3-D atlas structures in combination with tomographic and histological image data. The tool allows visualization and analysis of the reconstructed atlas framework, surface modeling and rotation of selected structures, user-defined slicing at any chosen angle, and import of data produced by the user for merging with the atlas framework. Tomographic image data in NIfTI (Neuroimaging Informatics Technology Initiative) file format, VRML and PNG files can be imported and visualized within the atlas framework. XYZ coordinate lists are also supported. Atlases that are available with the tool include mouse brain structures (3-D reconstructed from The Mouse Brain in Stereotaxic Coordinates by Paxinos and Franklin (2001)) and rat brain structures (3-D reconstructed from The Rat Brain in Stereotaxic Coordinates by Paxinos and Watson (2005)). Experimental data can be imported in Atlas3D and warped to atlas space, using manual linear registration, with the possibility to scale, rotate, and position the imported data. This facilitates assignment of location and comparative analysis of signal location in tomographic images. analysis, brain, histological, mouse, rat, slicing, structure, 3d, tomographic, visualization, neuroimaging, image, magnetic resonance, visualization is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
has parent organization: University of Oslo; Oslo; Norway
Research Council of Norway ;
NIH ;
NIBIB R01-EB00790;
NCRR U24-RR021382
Free, Freely available nif-0000-10373 http://www.nitrc.org/projects/incf_atlas3d SCR_001808 Neural Systems and Graphics Computing Laboratory: Atlas3D Software, NeSys Atlas3D 2026-07-28 09:40:25 17
MS lesion segmentation challenge 2008
 
Resource Report
Resource Website
1+ mentions
MS lesion segmentation challenge 2008 (RRID:SCR_002425) MS Lesion Segmentation 08 data or information resource, data set, narrative resource, training material Training material for the MS lesion segmentation challenge 2008 to compare different algorithms to segment the MS lesions from brain MRI scans. Data used for the workshop is composed of 54 brain MRI images and represents a range of patients and pathology which was acquired from Children's Hospital Boston and University of North Carolian. Data has initially been randomized into three groups: 20 training MRI images, 24 testing images for the qualifying and 8 for the onsite contest at the 2008 workshop. The downloadable online database consists now of the training images (including reference segmentations) and all the 32 combined testing images (without segmentations). The naming has not been changed in comparison to the workshop compeition in order to allow easy comparison between the workshop papers and the online database papers. One dataset has been removed (UNC_test1_Case02) due to considerable motion present only in its T2 image (without motion artifacts in T1 and FLAIR). Such a dataset unfairly penalizes methods that use T2 images versus methods that don't use the T2 image. Currently all cases have been segmented by expert raters at each institution. They have significant intersite variablility in segmentation. MS lesion MRI image data for this competition was acquired seperately by Children's Hospital Boston and University of North Carolina. UNC cases were acquired on Siemens 3T Allegra MRI scanner with slice thickness of 1mm and in-plane resolution of 0.5mm. To ease the segmentation process all data has been rigidly registered to a common reference frame and resliced to isotrophic voxel spacing using b-spline based interpolation. Pre-processed data is stored in NRRD format containing an ASCII readable header and a separate uncompressed raw image data file. This format is ITK compatible. If you want to join the competition, you can download data set from links here, and submit your segmentation results at http://www.ia.unc.edu/MSseg after registering your team. They require team name, password, and email address for future contact. Once experiment is completed, you can submit the segmentation data in a zip file format. Please refer submission page for uploading data format. magnetic resonance, competition, challenge, segmentation, segment, ms lesion, brain, mri scan, mri, image collection is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
has parent organization: University of North Carolina at Chapel Hill School of Medicine; North Carolina; USA
Multiple Sclerosis NIH Roadmap for Medical Research ;
NIBIB U54 EB005149-01
Free, Available for download, Freely available nlx_155799 SCR_002425 2008 MICCAI MS Lesion Segmentation Challenge 2026-07-28 09:40:25 1
WFU Biological Parametric Mapping Toolbox
 
Resource Report
Resource Website
1+ mentions
WFU Biological Parametric Mapping Toolbox (RRID:SCR_002613) WFU_BPM, WFU BPM software application, software toolkit, software resource, data processing software, image analysis software Software toolbox that performs SPM analysis with voxel-wise imaging covariates. The BPM toolbox incorporates information obtained from other modalities as regressors in a voxel-wise analysis, thereby permitting investigation of more sophisticated hypotheses. The BPM toolbox has been developed in Matlab with a user-friendly interface for performing analyses, including voxel-wise multimodal correlation, ANCOVA, and multiple regression. It has a high degree of integration with the SPM (statistical parametric mapping) software relying on it for visualization and statistical inference. Furthermore, statistical inference for a correlation field, rather than a widely used T-field, has been implemented in the correlation analysis for more accurate results. Requirements: * SPM2 or SPM5 * MATLAB version 6.5 or higher analyze, matlab, microsoft, magnetic resonance, nifti, posix/unix-like, statistical operation, win32 (ms windows), windows is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
is related to: SPM
has parent organization: Wake Forest School of Medicine; North Carolina; USA
Human Brain Project ;
NIBIB 1R01EB004673
PMID:17070709 Free, Available for download, Freely available nlx_156016 http://www.nitrc.org/projects/wfu_bpm SCR_002613 BPM - Integrated Tool for Biological Parametric Mapping, WFU Biological Parametric Mapping, BPM toolbox, BPM 2026-07-28 09:40:28 4
FFT Library
 
Resource Report
Resource Website
FFT Library (RRID:SCR_002698) FFT Library software application, software resource, data processing software, software library, image processing software, software toolkit Java library used for the execution of discrete Fourier transforms in 1-D, 2-D and 3-D through the implementation of Fast Fourier Transform (FFT) algorithms. * The FFT library has been written in Java for portability across different platforms, integrated into a single jar file for easy implementation. * The FFT library provides forward and backward fast Fourier transforms in 1-D, 2-D and 3-D with an easy-to-use manner. * The FFT requires the length equal to a number with an integer power of two. This library automatically examines the input data and detects the length to prevent improper execution. fourier transform, fast fourier transform, magnetic resonance is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
is listed by: Biositemaps
has parent organization: Laboratory of Neuro Imaging
NIBIB 9P41EB015922-15;
NCRR 2-P41-RR-013642-15;
NCRR U54 RR021813
PMID:24822428 Free, Freely available nif-0000-23324 http://www.nitrc.org/projects/fft http://www.loni.ucla.edu/Software/FFT SCR_002698 Fast Fourier Transform JavaLibrary, FFT Java library, Fast Fourier Transform Library, Fast Fourier Transform (FFT) JavaLibrary 2026-07-28 09:40:30 0
Synchronized Histological Image Viewing Architecture
 
Resource Report
Resource Website
Synchronized Histological Image Viewing Architecture (RRID:SCR_002690) SHIVA software application, d visualization software, software resource, data processing software, image processing software, image analysis software A Java-based visualization and analysis application that can process 2D and 3D image files and provides convenient methods for users to overlay multiple datasets. * Simultaneous visualization of multiple image volumes. * Tools for labeling and masking of structures. * Framework for the Mouse Atlas Project. data visualization, image analysis, 3d image, image, microscopy, magnetic resonance, java, manifold viewer is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
is listed by: Biositemaps
has parent organization: Laboratory of Neuro Imaging
NIBIB 9P41EB015922-15;
NCRR 2-P41-RR-013642-15
Free, Freely available nif-0000-23318 http://www.nitrc.org/projects/shiva SCR_002690 Synchronized Histological Image View Arc 2026-07-28 09:40:39 0
Non-Rigid Image Registration Evaluation Project
 
Resource Report
Resource Website
1+ mentions
Non-Rigid Image Registration Evaluation Project (RRID:SCR_002505) NIREP narrative resource, data or information resource, database, standard specification, software resource Project to develop software tools and provide shared image validation databases for rigorous testing of non-rigid image registration algorithms. NIREP will extend the scope of prior validation projects by developing evaluation criteria and metrics using large image populations, using richly annotated image databases, using computer simulated data, and increasing the number and types of evaluation criteria. The goal of this project is to establish, maintain, and endorse a standardized set of relevant benchmarks and metrics for performance evaluation of nonrigid image registration algorithms. Furthermore, these standards will be incorporated into an exportable computer program to automatically evaluate the registration accuracy of nonrigid image registration algorithms. magnetic resonance, registration software is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
has parent organization: University of Iowa; Iowa; USA
NIBIB R33 EB004126 THIS RESOURCE IS NO LONGER IN SERVICE nlx_155904 http://www.nitrc.org/projects/nirep SCR_002505 Non-Rigid Image Registration Evaluation Project, Non-Rigid Image Registration Evaluation Project (NIREP) 2026-07-28 09:40:26 7
Center for Gamma Ray Imaging
 
Resource Report
Resource Website
Center for Gamma Ray Imaging (RRID:SCR_001384) Center for Gamma-Ray Imaging material service resource, service resource, production service resource, instrument manufacture Biomedical technology resource center that develops new gamma-ray imaging instruments and techniques that yield substantially improved spatial and temporal resolutions. The Center makes its imagers and expertise available to a wide community of biomedical and clinical researchers through collaborative and service-oriented interactions. The collaborative research applies these new imaging tools to basic research in functional genomics, proteomics, cancer, cardiovascular disease and cognitive neuroscience, and to clinical research in tumor detection and other selected topics. There are five core research projects: * Detector technology research and development * Reconstruction algorithms and system modeling * Data acquisition, signal processing, and system development * Image-quality assessment and system optimization * Techniques for molecular imaging spect, ct, imaging, clinical, gamma-ray, imaging instrument, basic research, functional genomics, cardiovascular disease, cognitive neuroscience, breast cancer, tumor detection, proteomics, cancer has parent organization: University of Arizona; Arizona; USA NIBIB EB002035-14 nlx_152567 SCR_001384 2026-07-28 09:40:10 0
National ESCA and Surface Analysis Center for Biomedical Problems
 
Resource Report
Resource Website
1+ mentions
National ESCA and Surface Analysis Center for Biomedical Problems (RRID:SCR_001430) NESAC/BIO service resource, biomaterial analysis service, biomedical technology research center, training resource, production service resource, material analysis service, access service resource, analysis service resource Biomedical technology research center that provides state-of-the-art surface analysis expertise, instrumentation, experimental protocols, and data analysis methods to address surface-related biomedical problems. NESAC/BIO develops and applies surface science methodologies that produce a full understanding of the surface composition, structure, spatial distribution, and orientation of biomaterials and adsorbed biomolecules. The NESAC/BIO program identifies areas where surface science must evolve to keep pace with the growth in biochemical knowledge and biomaterial fabrication technology, and develops instrumentation, experimental protocols, and data analysis methods to achieve this evolution. NESAC/BIO provides state-of-the-art surface analysis tools to researchers in the biomedical community. You can gain access to the NESAC/BIO facilities in one of the following ways: * Collaborative: Propose a project to collaborate on with NESAC/BIO. The project should be rewarding for both groups, and the results should reflect the utility of surface analysis for biomedical research * Service: Ask NESAC/BIO to analyze your biomaterial specimens. The spectra obtained from the analyses will be interpreted for you. * Training: Visit the University of Washington to receive training in surface analysis and personally run experiments for your individual research projects. These experiments should have a high probability for yielding useful information and should not involve the development of new ESCA techniques or methodologies. surface, composition, structure, spatial distribution, orientation, biomaterial, biomolecule, surface science, biochemical, biomaterial fabrication, surface analysis has parent organization: University of Washington; Seattle; USA NIBIB 5P41RR001296-11 Free, Freely Available nlx_152654 SCR_001430 NESAC/BIO - National ESCA and Surface Analysis Center for Biomedical Problems 2026-07-28 09:40:16 1
MRI Studio
 
Resource Report
Resource Website
100+ mentions
MRI Studio (RRID:SCR_001398) software application, software resource, data processing software, data visualization software, image processing software, image analysis software An image processing program running under Windows suitable for such tasks as tensor calculation, color mapping, fiber tracking, and 3D visualization. Most of operations can be done with only a few clicks. This tool evolved from DTI Studio. Tools in the program can be grouped in the following way: * Image Viewer * Diffusion Tensor Calculations * Fiber Tracking and Editing * 3D Visualization * Image File Management * Region of Interesting (ROI) Drawing and Statistics * Image Registration tensor calculation, color mapping, fiber tracking, 3d visualization, dti, image registration, mri, diffusion mr fiber tracking, microsoft, c++, analyze is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
is related to: Diffusion Tensor Imaging ToolKit
has parent organization: Johns Hopkins University; Maryland; USA
works with: UManitoba - JHU Functionally Defined Human White Matter Atlas
NCRR ;
Biomedical Informatics Research Network ;
NIBIB
Free, Freely Available nif-0000-00291 http://www.nitrc.org/projects/mri_studio SCR_001398 dtiStudio, DTI Studio 2026-07-28 09:40:11 165
PNEUMA
 
Resource Report
Resource Website
1+ mentions
PNEUMA (RRID:SCR_001391) PNEUMA software application, simulation software, software toolkit, software resource A set of modules that are used to simulate the autoregulation of the cardiovascular and respiratory systems under conditions of changing sleep-wake state and a variety of physiological and pharmacological interventions. It models the dynamic interactions that take place among the various component mechanisms, including those involved in the chemical control of breathing, heart rate, and blood pressure, as well as the effects of changes in the sleep-wake state and arousal from sleep. PNEUMA includes the autonomic control of the cardiovascular system, chemoreflex and state-related control of breath-to-breath ventilation, state-related and chemoreflex control of upper airway potency, as well as respiratory and circulatory mechanics. The model is capable of simulating the cardiorespiratory responses to sleep onset, arousal, continuous positive airway pressure, the administration of inhaled carbon dioxide and oxygen, Valsalva and Mueller maneuvers, and Cheyne-Stokes respiration during sleep. In PNEUMA 3.0, we have extended the existing integrative model of respiratory, cardiovascular, and sleepwake state control, to incorporate a sub-model of glucoseinsulinfatty acid regulation. The extended model is capable of simulating the metabolic control of glucoseinsulin dynamics and its interactions with the autonomic nervous system. The interactions between autonomic and metabolic control include the circadian regulation of epinephrine secretion, epinephrine regulation on dynamic fluctuations in glucose and free fatty acids in plasma, metabolic coupling among tissues and organs mediated by insulin and epinephrine, as well as the effect of insulin on peripheral vascular sympathetic activity. This extended model represents a starting point from which further in silico investigations into the interaction between the autonomic nervous system and the metabolic control system can proceed. Features in PNEUMA 3.0 * Incorporates metabolic component based on prior models of glucose-insulin regulation and free fatty acid (FFA) regulation. * Changes in sympathetic activity from the autonomic portion of PNEUMA produce changes in epinephrine output, which in turn affects the metabolic sub-model. * Inputs from the dietary intake of glucose and external interventions, such as insulin injections, have also been incorporated. * Also incorporated is autonomic feedback from the metabolic component to the rest of PNEUMA: changes in insulin level lead to changes in sympathetic tone. System Requirements: PNEUMA requires Matlab R2007b or higher with the accompanying version of Simulink to be installed on your computer. matlab, simulate, autoregulation, cardiovascular system, respiratory system, sleep-wake state, physiological intervention, pharmacological intervention, drug, breathing, heart rate, blood pressure, respiration, glucose, insulin, fatty acid, regulation, autonomic nervous system, chemoreflex, ventilation, circulation, cardiorespiratory, metabolic control system, circadian, regulation, epinephrine has parent organization: Biomedical Simulations Resource NIBIB P41-EB001978;
NCRR P41-RR01861
PMID:17271149 Free, Freely Available nlx_152572 SCR_001391 2026-07-28 09:40:10 3

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