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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
flytrap
 
Resource Report
Resource Website
10+ mentions
flytrap (RRID:SCR_003075) Flytrap video resource, data or information resource, database, image Flytrap is an interactive database for displaying gene expression patterns, in particular P(GAL4) patterns, via an intuitive WWW based interface. This development consists of two components, the first being the HTML interface to the database and the second, a tool-kit for constructing and maintaining the database. The browser component of the project is entirely platform independent; based on javascript and HTML and therefore only requires a "standard" browser. This is to facilitate CD-ROM distribution and off-line browsing. Whether on-line or on CD, the basic browser structure does not reply on any server based scripts. Basic searching is now available. The search page uses javascript and will work off-line (i.e. from a CD-ROM copy). The construction tool-kit is UNIX based and requires an on-line web server. The tool-kit is used to compile the HTML browser interface from a simple database. The tool-kit part comprises a forms based HTML interface to the datasets allowing new information to b e added and updated very simply. We are also developing a java interface for the tool-kit that will enable us to edit and annotate images on-line. The basic browser interface is complete and a demonstration version can be accessed via the website. The first working version of the tool-kit is now on-line and is available for use. brain, genetics, 3d model, expression pattern, anatomy, anatomical structure, cell, gene expression, brain function, neuroimaging, FASEB list has parent organization: University of Edinburgh; Scotland; United Kingdom BBSRC ;
EPSRC
PMID:14681446 Free, Freely available nif-0000-00051, r3d100011203 https://doi.org/10.17616/R3VD0P SCR_003075 2026-07-30 09:26:47 48
REDfly Regulatory Element Database for Drosophilia
 
Resource Report
Resource Website
10+ mentions
REDfly Regulatory Element Database for Drosophilia (RRID:SCR_006790) REDfly service resource, data repository, data or information resource, database, storage service resource Curated collection of known Drosophila transcriptional cis-regulatory modules (CRMs) and transcription factor binding sites (TFBSs). Includes experimentally verified fly regulatory elements along with their DNA sequence, associated genes, and expression patterns they direct. Submission of experimentally verified cis-regulatory elements that are not included in REDfly database are welcome. transcriptional cis-regulatory module, transcription factor binding site, dna sequence, gene, expression pattern, genome, gene expression, transcription factor, cis-regulatory module, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is related to: Drosophila anatomy and development ontologies
is related to: FlyMine
has parent organization: University at Buffalo; New York; USA
NSF EF0843229;
NIGMS U24 GM144232
PMID:20965965
PMID:18039705
PMID:16303794
Acknowledgement requested OMICS_01870, biotools:redfly, nif-0000-03393 https://bio.tools/redfly SCR_006790 Regulatory Element Database for Drosophilia, Regulatory Element Database 2026-07-30 09:27:30 14
Evolutionary Rate Covariation
 
Resource Report
Resource Website
1+ mentions
Evolutionary Rate Covariation (RRID:SCR_015669) ERC data processing software, web application, data analysis software, software resource, software application Web-based statistical application that measures correlated rates across a phylogeny, allowing for extraction of genes with similar evolutionary histories. It can identify new functional connections between genes. statistical software, correlation, phylogeny, gene extraction, genetic evolutionary history, covariation, group analysis PMID:25679399
PMID:24453993
PMID:22287101
Freely available, Free, Available for download SCR_015669 ERC: Evolutionary Rate Covariation, Evolutionary Rate Covariation (ERC) Analysis, Evolutionary Rate Covariation (ERC) 2026-07-30 09:29:56 1
OpenFlyData.org
 
Resource Report
Resource Website
OpenFlyData.org (RRID:SCR_004807) OpenFlyData.org data access protocol, image collection, software resource, web service, data or information resource, database A cross-database search service for Drosophila gene expression data, including microarray data from FlyAtlas and in situ images from BDGP and Fly-TED. The applications provide different ways to search for and compare gene expression data for the fruit fly Drosophila melanogaster. You may Search Gene Expression Data by Gene, Gene Batch, and by Tissue Expression Profile. A number of Web services (SPARQL endpoints) are provided from this site which may be queried programmatically for data. microarray, in situ, gene expression, gene, open fly data, openflydata, openflydata, expression, in situ hybridization is related to: FlyAtlas: the Drosophila gene expression atlas
is related to: Berkeley Drosophila Genome Project
has parent organization: FlyWeb Project
JISC PMID:20382263 nlx_79461 SCR_004807 open fly data, OpenFlyData, openflydata 2026-07-30 09:27:07 0
Centroid Trajectory Analysis
 
Resource Report
Resource Website
10+ mentions
Centroid Trajectory Analysis (RRID:SCR_006331) CeTrAn data processing software, software application, data analysis software, software resource Open source software written in R that tracks a single animal walking in a homogenous environment (Buritrack) and analyzes its trajectory. It extracts eleven metrics and includes correlation analyses and a Principal Components Analysis (PCA). It was designed to be easily customized to personal requirements. In combination with inexpensive hardware, these tools can readily be used for teaching and research purposes. Buritrack is a program to track individual Drosophila fruit flies online with any camera as they walk in Buridan's paradigm. The program extracts the coordinate locations of the fly and stores them in a text file. trajectory, buridan, principal components analysis, correlation analysis, buridan's paradigm, locomotion, software, tracking, drosophila has parent organization: Free University of Berlin; Berlin; Germany
has parent organization: SourceForge
Swiss National Science Foundation PA00P3_124141;
EPSRC EP/F030673/1
PMID:22912692 Open source, Available for Mac and PC, Source code available for download nlx_152033 SCR_006331 CeTrAn: centroid trajectory analysis 2026-07-30 09:27:22 11
Drosophila induction-based torque compensator
 
Resource Report
Resource Website
1+ mentions
Drosophila induction-based torque compensator (RRID:SCR_017276) instrument resource Compensator measure rotational force of tethered fly around its vertical body axis (yaw torque). Used as behavioral read-out after sensory stimulation or to control various environmental stimuli in different kinds of behavioral experiments. Measurement device uses measurement principle that is based on magnetic induction and compensates for any movement of fly. compensator, torque, yaw, insect, Diptera, time series, sensory, stimulation, fly, rotational, force, vertical, body, axis, tethered SCR_017276 2026-07-25 12:08:30 1
miRNA
 
Resource Report
Resource Website
10+ mentions
miRNA (RRID:SCR_010849) miRNA data or information resource, data set Data set of 2003 and 2005 miRNA-Target predictions for Drosophila miRNAs. is listed by: OMICtools
has parent organization: European Molecular Biology Laboratory
PMID:16337999
PMID:15723116
PMID:14691535
OMICS_00407 SCR_010849 miRNA - Target Gene Prediction at EMBL 2026-07-27 09:33:49 41
PITA
 
Resource Report
Resource Website
1000+ mentions
PITA (RRID:SCR_010853) PITA data or information resource, data set Catalogs of predicted microRNA targets in worm (based on ce6 genome assembly), fly (dm3), mouse (mm9) and human (hg18). We follow standard seed parameter settings and consider seeds of length 6-8 bases, beginning at position 2 of the microRNA. No mismatches or loops are allowed, but a single G:U wobble is allowed in 7- or 8-mers. In genes missing a 3' UTR annotation, 500 bp (fly), 800 bp (human and mouse) or 300 bp (worm) downstream of the annotated end of the coding sequence were used as the predicted UTR. For each organism, a catalog with zero flank and with a flank of 3 and 15 bases upstream and downstream. is listed by: OMICtools OMICS_00412 SCR_010853 2026-07-27 09:33:49 1047
Target genes of Wnt/beta-catenin signaling
 
Resource Report
Resource Website
10+ mentions
Target genes of Wnt/beta-catenin signaling (RRID:SCR_007022) Target genes of Wnt/beta-catenin signaling data or information resource, data set A list of target genes of Wnt/beta-catenin signaling. Suggestions for additions are welcome. Direct targets are defined as those with Tcf binding sites and demonstrating that these sites are important. target gene, wnt/beta-catenin signaling, wnt, beta-catenin, signaling, gene has parent organization: Stanford University; Stanford; California Colon cancer, Tumor, Adenocarcinoma, Melanoma, Cancer The community can contribute to this resource nlx_156867 SCR_007022 2026-07-27 09:32:43 24
Kyoto Stock Center
 
Resource Report
Resource Website
1+ mentions
Kyoto Stock Center (RRID:SCR_008469) DGGR organism supplier, biomaterial supply resource, material resource Organism supplier which collects Drosophila stocks from laboratories all over the world, maintains them, and provides them to researchers upon request. RIN, Resource Information Network, organism supplier, drosophila, genomics, genetic resource, RRID Community Authority is used by: Integrated Animals
is listed by: Resource Information Network
Available to the research community nif-0000-30415 SCR_008469 Drosophila Genomics and Genetic Resources, Drosophila Genetic Resource Center, The Drosophila Genetic Resource Center, Kyoto DGGR 2026-07-28 09:42:20 3
Segmented ssTEM stack of neural tissue
 
Resource Report
Resource Website
1+ mentions
Segmented ssTEM stack of neural tissue (RRID:SCR_007004) Segmented ssTEM stack of neural tissue data or information resource, data set, image 30 sections from a serial section Transmission Electron Microscopy (ssTEM) data set of the Drosophila first instar larva ventral nerve cord (VNC). The microcube measures 2 x 2 x 1.5 microns approx., with a resolution of 4x4x50 nm/pixel. The images are representative of actual images in the real-world: there is a bit of noise; there are image registration errors; there is even a small stitching error in one section. None of these led to any difficulties in the manual labeling of each element in the image stack by an expert human neuroanatomist. A software application that aims at removing or reducing human operation must be able to cope with all these issues. Each labeled object has a unique id and fits into the overall datastructure of the data set. For example, each mitochondria is represented by a unique Arealist object, containing a list of labeled areas, one per section. All membranes have been highlighted as one unique object. All neurites (and glia) have been highlighted each as its own independent object, delimited by membrane and non-overlapping with membrane and with each other. On the other hand, mitochondria, noise and synapses overlap with membranes, neurites and glia; hence, they are offered as independent tif stacks. ventral nerve cord, transmission electron microscopy, mitochondria, synapse, membrane, neurite, glia, noise, section is related to: TrakEM2
has parent organization: University of Zurich; Zurich; Switzerland
PMID:20957184 Free for the purpose of generating or testing non-commercial image segmentation software. If any scientific publications derive from the usage of this data set, You must cite as specified. nlx_151926 SCR_007004 2026-07-28 09:41:40 4
Unified Human Interactome
 
Resource Report
Resource Website
10+ mentions
Unified Human Interactome (RRID:SCR_005805) UniHI data or information resource, database A database of human molecular interaction networks that integrates human protein-protein and transcriptional regulatory interactions from 15 distinct resources and aims to give direct and easy access to the integrated data set and to enable users to perform network-based investigations. The database includes tools (i) to search for molecular interaction partners of query genes or proteins in the integrated dataset, (ii) to inspect the origin, evidence and functional annotation of retrieved proteins and interactions, (iii) to visualize and adjust the resulting interaction network, (iv) to filter interactions based on method of derivation, evidence and type of experiment as well as based on gene expression data or gene lists and (v) to analyze the functional composition of interaction networks. molecular interaction network, interactome, protein, protein interaction network, protein interaction, pathway, function, visualization, protein-protein interaction, transcriptional regulatory interaction, network is listed by: OMICtools
has parent organization: University of Algarve; Faro; Portugal
PMID:24214987
PMID:22218860
PMID:18984619
PMID:17158159
Public, Non-commercial OMICS_01911, nif-0000-03609 http://www.mdc-berlin.de/unihi SCR_005805 2026-07-28 09:41:21 19
DroID - Drosophila Interactions Database
 
Resource Report
Resource Website
10+ mentions
DroID - Drosophila Interactions Database (RRID:SCR_006634) DroID data or information resource, database A gene and protein interactions database designed specifically for the model organism Drosophila including protein-protein, transcription factor-gene, microRNA-gene, and genetic interactions. For advanced searches and dynamic graphing capabilities the IM Browser and a DroID Cytoscape plugin are available. interaction, gene, protein, protein interaction, annotation, transcription factor, rna, protein-protein interaction, interactome, gene expression, phenotype, interolog, ortholog is listed by: OMICtools
is related to: Cytoscape
has parent organization: Wayne State University School of Medicine; Michigan; USA
PMID:21036869
PMID:18840285
Free, Public, Acknowledgement requested nif-0000-02767, OMICS_01908 SCR_006634 DroID - The Drosophila Interactions Database 2026-07-28 09:41:36 35
Drosophila polymorphism database
 
Resource Report
Resource Website
1+ mentions
Drosophila polymorphism database (RRID:SCR_007629) DPDB data or information resource, database Database providing a collection of all the existing polymorphic sequences in the Drosophila genus. It allows users to search for any polymorphic set according to different parameter values of nucleotide diversity. For data collection, diversity measures and updating they use PDA, a pipeline made of a set of Perl modules that automates the process of sequence retrieving, grouping, aligning and estimating diversity parameters from GenBank sequences. Diversity measures, including polymorphism estimates in synonymous and non-synonymous sites, linkage disequilibrium and codon bias, are calculated for each polymorphic set in different functional regions. The database also includes the primary information retrieved from different external sources: the Drosophila publicly available nucleotide sequences (excluding ESTs, STSs, GSSs, working draft and patents) with their annotations and references from GenBank (see the NCBI's Disclaimer and Copyright), additional information of genes and aberrations (from FlyBase), and the cross-references to the PopSet database (from NCBI). The database content is updated daily and records are assigned unique and permanent DPDB identification numbers to facilitate cross-database referencing. polymorphism has parent organization: Autonomous University of Barcelona; Barcelona; Spain nif-0000-02769 SCR_007629 2026-07-28 09:41:50 1
FlyBase
 
Resource Report
Resource Website
1000+ mentions
FlyBase (RRID:SCR_006549) FB organism-related portal, service resource, data repository, portal, topical portal, data or information resource, database, storage service resource Database of Drosophila genetic and genomic information with information about stock collections and fly genetic tools. Gene Ontology (GO) terms are used to describe three attributes of wild-type gene products: their molecular function, the biological processes in which they play a role, and their subcellular location. Additionally, FlyBase accepts data submissions. FlyBase can be searched for genes, alleles, aberrations and other genetic objects, phenotypes, sequences, stocks, images and movies, controlled terms, and Drosophila researchers using the tools available from the "Tools" drop-down menu in the Navigation bar. RIN, Resource Information Network, mutant, gene, genome, blast, genotype, phenotype, allele, sequence, stock, image, movie, controlled term, video resource, image collection, life-cycle, genome, expression, rna-seq, genetics, drosophilidae, bio.tools, FASEB list, RRID Community Authority is used by: NIF Data Federation
is used by: Resource Identification Portal
is used by: PhenoGO
is used by: Integrated Animals
is used by: Drososhare
is recommended by: NIDDK Information Network (dkNET)
is recommended by: National Library of Medicine
is recommended by: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
is listed by: re3data.org
is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is listed by: Resource Information Network
is related to: FlyMine
is related to: Virtual Fly Brain
is related to: AmiGO
is related to: Drosophila melanogaster Exon Database
is related to: HomoloGene
is related to: UniParc at the EBI
is related to: UniParc
is related to: Gene Ontology
is related to: NIH Data Sharing Repositories
is related to: GBrowse
is related to: Integrated Manually Extracted Annotation
is related to: PhenoGO
has parent organization: Harvard University; Cambridge; United States
has parent organization: University of Cambridge; Cambridge; United Kingdom
has parent organization: Indiana University; Indiana; USA
has parent organization: University of New Mexico; New Mexico; USA
is parent organization of: Drosophila anatomy and development ontologies
is parent organization of: Fly Taxonomy
is parent organization of: FlyBase Controlled Vocabulary
is parent organization of: Drosophila Development Ontology
is organization facet of: Alliance of Genome Resources
MRC ;
Indiana Genomics Initiative ;
NSF ;
NIH Blueprint for Neuroscience Research ;
NIHGRI P41 HG000739
PMID:24234449
PMID:22127867
PMID:18948289
PMID:18641940
PMID:18160408
PMID:17099233
PMID:16381917
PMID:15608223
PMID:12519974
PMID:11752267
PMID:11465064
PMID:9847148
PMID:9399806
PMID:9045212
PMID:8594600
PMID:8578603
PMID:7937045
PMID:7925011
nif-0000-00558, r3d100010591, OMICS_01649, biotools:flybase https://bio.tools/flybase, https://doi.org/10.17616/R3903Q http://flybase.net SCR_006549 flybase A Drosophila Genomic and Genetic Database, FlyBase: A Database of Drosophila Genes and Genomes, FLYBASE, FlyBase: A Database of Drosophila Genes & Genomes, FB 2026-07-30 09:27:24 4025
Smart Dictionary Lookup
 
Resource Report
Resource Website
Smart Dictionary Lookup (RRID:SCR_000568) Smart Dictionary Lookup data or information resource, database, service resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 9, 2022. System that retrieves relevant UniProt IDs from BioThesaurus entries using a soft string matching algorithm. gene, protein uses: UniProt
uses: BioThesaurus
is listed by: OMICtools
has parent organization: University of Manchester; Manchester; United Kingdom
PMID:17698493 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_01198 SCR_000568 2026-07-30 09:26:00 0
CRCView
 
Resource Report
Resource Website
CRCView (RRID:SCR_007092) CRCView service resource, production service resource, analysis service resource, data analysis service Web-based microarray data analysis and visualization system powered by CRC, or Chinese Restaurant cluster, a Dirichlet process model-based clustering algorithm recently developed by Dr. Steve Qin. It also incorporates several gene expression analysis programs from Bioconductor, including GOStats, genefilter, and Heatplus. CRCView also installs from the Bioconductor system 78 annotation libraries of microarray chips for human (31), mouse (24), rat (14), zebrafish (1), chicken (1), Drosophila (3), Arabidopsis (2), Caenorhabditis elegans (1), and Xenopus Laevis (1). CRCView allows flexible input data format, automated model-based CRC clustering analysis, rich graphical illustration, and integrated Gene Ontology (GO)-based gene enrichment for efficient annotation and interpretation of clustering results. CRC has the following features comparing to other clustering tools: 1) able to infer number of clusters, 2) able to cluster genes displaying time-shifted and/or inverted correlations, 3) able to tolerate missing genotype data and 4) provide confidence measure for clusters generated. You need to register for an account in the system to store your data and analyses. The data and results can be visited again anytime you log in. microarray, gene expression, cluster, gene, expression profile, data repository, bio.tools is listed by: bio.tools
is listed by: Debian
is related to: Bioconductor
is related to: Gene Ontology
has parent organization: University of Michigan; Ann Arbor; USA
University of Michigan; Michigan; USA ;
Institutional Fund ;
NIH U013422;
NIAID 1R21AI057875-01
PMID:17485426 Registration required biotools:crcview, nlx_99864 https://bio.tools/crcview http://helab.bioinformatics.med.umich.edu/crcview/ SCR_007092 Chinese Restaurant ClusterView 2026-07-30 09:27:34 0
Flybrain at Stanford
 
Resource Report
Resource Website
1+ mentions
Flybrain at Stanford (RRID:SCR_001877) Flybrain(at)Stanford, FlybrainatStanford data processing software, image collection, software resource, image analysis software, data or information resource, software application Project content including raw image data, neuronal tracings, image registration tools and analysis scripts covering three manuscripts: Comprehensive Maps of DrosophilaHigher Olfactory Centres : Spatially Segregated Fruit and Pheromone Representation which uses single cell labeling and image registration to describe the organization of the higher olfactory centers of Drosophila; Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe which uses single cell labeling to describe the organization of the antennal lobe local interneurons; and Sexual Dimorphism in the Fly Brain which uses clonal analysis and image registration to identify a large number of sex differences in the brain and VNC of Drosophila. Data * Raw Data of Reference Brain (pic, amira) (both seed and average) * Label field of LH and MB calyx and surfaces for these structures * Label field of neuropil of Reference Brain * Traces (before and after registration). Neurolucida, SWC and AmiraMesh lineset. * MB and LH Density Data for different classes of neuron. In R format and as separate amira files. * Registration files for all brains used in the study * MBLH confocal images for all brains actually used in the study (Biorad pic format) * Sample confocal images for antennal lobe of every PN class * Confocal stacks of GABA stained ventral PNs Programs * ImageJ plugins (Biorad reader /writer/Amira reader/writer/IGS raw Reader) * Binary of registration, warp and gregxform (macosx only, others on request) * Simple GUI for registration tools (macosx only at present) * R analysis/visualization functions * Amira Script to show examples of neuronal classes The website is a collaboration between the labs of Greg Jefferis and Liqun Luo and has been built by Chris Potter and Greg Jefferis. The core Image Registration tools were created by Torsten Rohlfing and Calvin Maurer. brain, cell, neuron, neuropil, olfactory, pheromone, confocal image, antennal lobe, axon trace, forum, neuronal tracing, image registration tool, analysis script, single-cell labeling, image registration, mushroom body, lateral horn, olfactory receptor neuron has parent organization: Stanford University; Stanford; California Wellcome Trust WT076726;
Damon Runyon Cancer Research Foundation DRG-1766-03;
NIAAA AA05965;
NIAAA AA13521;
NIDCD R01-DC005982
PMID:17382886 THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-10437 SCR_001877 Flybrain (at) Stanford - A warped brain is a good thing, Flybrain (at) Stanford 2026-07-30 09:26:18 6
NeuroMorpho.Org
 
Resource Report
Resource Website
50+ mentions
NeuroMorpho.Org (RRID:SCR_002145) service resource, data repository, data or information resource, database, storage service resource Centrally curated inventory of digitally reconstructed neurons associated with peer-reviewed publications that contains some of the most complete axonal arborizations digitally available in the community. Each neuron is represented by a unique identifier, general information (metadata), the original and standardized ASCII files of the digital morphological reconstruction, and a set of morphometric features. It contains contributions from over 100 laboratories worldwide and is continuously updated as new morphological reconstructions are collected, published, and shared. Users may browse by species, brain region, cell type or lab name. Users can also download morphological reconstructions for research and analysis. Deposition and distribution of reconstruction files ultimately prevents data loss. Centralized curation and annotation aims at minimizing the effort required by data owners while ensuring a unified format. It also provides a one-stop entry point for all available reconstructions, thus maximizing data visibility and impact. neuron, morphological reconstruction, morphometry, axonal arborization, digital neuronal reconstruction, neuronal reconstruction, neuronal morphology, data sharing, annotation, brain region, neocortex, digital reconstruction, neurogenetics, neurochemistry, neuroscience, neurology, FASEB list is used by: NIF Data Federation
is used by: BICCN
is recommended by: National Library of Medicine
is recommended by: NIDDK Information Network (dkNET)
is recommended by: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
is listed by: re3data.org
is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
is related to: DONE: Detection of Outlier NEurons
is related to: NIF Literature
is related to: Computational Neurobiology and Imaging Center
is related to: Integrated Manually Extracted Annotation
is related to: xyz2swc
is related to: Allen Institute for Brain Science
has parent organization: George Mason University; Virginia; USA
is parent organization of: NeuroMorpho.Org species ontology
is parent organization of: NeuroMorpho.Org species ontology old
NINDS R01 NS39600;
MURI ONR N000141010198
PMID:17728438
PMID:16552417
PMID:18949582
Free, Available for download, Freely available nif-0000-00006, r3d100010107 http://www.nitrc.org/projects/neuromorpho_org, http://neuromorpho.org/, https://doi.org/10.17616/R3WW2K SCR_002145 Neuro Morpho, NeuroMorpho.org, NeuroMorpho 2026-07-30 09:26:22 96
Fly EM
 
Resource Report
Resource Website
1+ mentions
Fly EM (RRID:SCR_002242) Fly EM, FlyEM data processing software, data set, segmentation software, software resource, portal, image analysis software, topical portal, data or information resource, software application A project producing datasets, software, and algorithms that is developing the technology to produce connectomes at the electron microscopic level of behaviorally-relevant neural circuits as well as the entire Drosophila nervous system. This technology will enable them to create a map of every neuron and synapse in the Drosophila nervous system, using novel approaches to electron microscopy (EM) as the foundation. In the same way that the fly genome paved the way for larger projects, including sequencing the human genome, Fly EM may ultimately contribute to our understanding of the human brain by establishing a fly "connectome" a map that shows how all neurons in the fly brain are connected to each other. They began their entry into EM reconstruction with the fly's adult visual system, where much is known about cell types from previous EM and histological studies, as well as ongoing studies in the Fly Light Project. In addition to establishing and publishing a fly connectome, Fly EM will make technology and methodology available that is needed to perform large-scale EM reconstructions. Fly EM will generally pursue an open policy with their datasets, software, and algorithms after relevant publications. When an EM reconstruction is published, the derived connectome and reconstructed neuronal skeletons will be made available online. The raw data and annotatations will be made available upon request as logistics dictate. To encourage further collaboration and scientific discovery, a small fraction of their raw data and corresponding segmentation will be made available independent of publication. Their goal is to enable others who wish to approach the many algorithmic challenges, but who do not have access to an EM facility, to have the data they need to support methods development, as well as their results to use as a benchmark. Fly EM emphasizes publication of supporting techniques and software approaches before major EM reconstruction releases to encourage rapid feedback from the community and adoption of their strategies. FlyEM maintains much of its software in the open-source repository GitHub:http://janelia-flyem.github.com. They will provide information on official release versions of these packages on git-hub when it reaches reasonable maturity. neuron, synapse, nervous system, electron microscopy, visual system, connectome, reconstruction, adult, optic lobe, medulla, lobula has parent organization: Janelia Research PMID:30033368 Janelia Farm license, A 3-clause BSD license nlx_155555 SCR_002242 Fly EM Project 2026-07-30 09:26:24 3

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