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The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6.

FEBS letters | Jan 15, 1999

http://www.ncbi.nlm.nih.gov/pubmed/9928991

The zinc finger protein A20 is encoded by an immediate early response gene whose expression is induced by different inflammatory stimuli, including interleukin-1 (IL-1). Gene induction by IL-1 is mediated by activation of the transcription factor NF-kappaB, and requires the signal adapter protein TRAF6. The latter interacts with the NF-kappaB-inducing kinase NIK, which is believed to be part of the IkappaB kinase complex. Expression of A20 potently inhibits IL-1-induced NF-kappaB activation by an unknown mechanism. Inhibition of IL-1-induced NF-kappaB activation was found to be mediated by the C-terminal zinc finger-containing domain of A20. More importantly, we present evidence that A20 interferes with IL-1-induced NF-kappaB activation at the level of TRAF6, upstream of NIK. Moreover, A20 was shown to directly interact with TRAF6.

Pubmed ID: 9928991 RIS Download

Mesh terms: Blotting, Western | Cell Line | DNA-Binding Proteins | Gene Expression Regulation | Humans | Interleukin-1 | Intracellular Signaling Peptides and Proteins | Kidney | NF-kappa B | Nuclear Proteins | Precipitin Tests | Protein-Serine-Threonine Kinases | Proteins | Sequence Deletion | Signal Transduction | TNF Receptor-Associated Factor 1 | TNF Receptor-Associated Factor 2 | TNF Receptor-Associated Factor 6 | Transcriptional Activation | Transfection | Tumor Necrosis Factor-alpha | Zinc Fingers