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A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins.

We have characterized a novel partner for androgen receptor (AR), termed ARIP3, that interacts with the DNA-binding domain/zinc finger region of AR and is predominantly expressed in the testis. Rat ARIP3 is a nuclear protein comprising 572 amino acids. It modulates AR-dependent but not basal transcription, suggesting that ARIP3 acts as an AR transcriptional coregulator. Except for the C-terminal AR-interacting domain, ARIP3 contains distinct regions that are also present in two recently described proteins, a protein inhibitor of activated Stat3 and an RNA helicase II-interacting protein (Gu/RH-II binding protein). Conserved structural features of these proteins indicate the existence of a gene family involved in the regulation of various transcription factors. Collectively, ARIP3 belongs to a novel nuclear protein family and is perhaps the first tissue-specific coregulator of androgen receptor.

Pubmed ID: 9920921

Authors

  • Moilanen AM
  • Karvonen U
  • Poukka H
  • Yan W
  • Toppari J
  • J√§nne OA
  • Palvimo JJ

Journal

The Journal of biological chemistry

Publication Data

February 5, 1999

Associated Grants

None

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • COS Cells
  • Male
  • Molecular Sequence Data
  • Nuclear Proteins
  • Protein Binding
  • Rats
  • Receptors, Androgen
  • Sequence Homology, Amino Acid
  • Subcellular Fractions
  • Testis
  • Transcription, Genetic
  • Transfection
  • Zinc Fingers