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Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest.

http://www.ncbi.nlm.nih.gov/pubmed/9891079

SWI-SNF complexes have been implicated in transcriptional regulation by chromatin remodeling. We have identified an interaction between two components of the mammalian SWI-SNF complex and cyclin E, an essential cell cycle regulatory protein required for G1/S transition. BRG1 and BAF155, mammalian homologs of yeast SWI2 and SWI3, respectively, are found in cyclin E complexes and are phosphorylated by cyclin E-associated kinase activity. In this report, we show that overexpression of BRG1 causes growth arrest and induction of senescence-associated beta-galactosidase activity, which can be overcome by cyclin E. Our results suggest that cyclin E may modulate the activity of the SWI-SNF apparatus to maintain the chromatin in a transcriptionally permissive state.

Pubmed ID: 9891079 RIS Download

Mesh terms: Amino Acid Sequence | Cell Cycle | Cell Line | Cell Size | Cyclin E | DNA Helicases | DNA-Binding Proteins | Fungal Proteins | Humans | Molecular Sequence Data | Nuclear Proteins | Phenotype | Retinoblastoma Protein | Saccharomyces cerevisiae Proteins | Trans-Activators | Transcription Factors | Transfection

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