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The ATM-related cofactor Tra1 is a component of the purified SAGA complex.

Molecular cell | Dec 26, 1998

The SAGA histone acetyltransferase/transcriptional adaptor complex is composed of multiple transcriptional regulators including Ada, Spt, and TAFII proteins. Here we identify an additional novel subunit of the complex, Tra1, an ATM/PI-3-kinase-related homolog of the human TRRAP cofactor, which is essential for c-Myc and E2F-mediated oncogenic transformation. Mass spectrometry, immunoblotting, and immunoprecipitation experiments confirm the stable association of this protein within SAGA. In addition, the Tra1 protein is a component of at least two other histone acetyltransferase protein complexes. These results indicate a role for Tra1 in the regulation of transcriptional activation through the recruitment of HAT activity to an activator-bound promoter.

Pubmed ID: 9885573 RIS Download

Mesh terms: Acetyltransferases | Amino Acid Sequence | Ataxia Telangiectasia Mutated Proteins | Cell Cycle Proteins | DNA-Binding Proteins | Electrophoresis, Polyacrylamide Gel | Fungal Proteins | Histone Acetyltransferases | Immunoblotting | Molecular Sequence Data | Multienzyme Complexes | Protein Kinases | Protein-Serine-Threonine Kinases | Proteins | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Tumor Suppressor Proteins

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Associated grants

  • Agency: PHS HHS, Id: 1182302

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