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The ATM-related cofactor Tra1 is a component of the purified SAGA complex.

The SAGA histone acetyltransferase/transcriptional adaptor complex is composed of multiple transcriptional regulators including Ada, Spt, and TAFII proteins. Here we identify an additional novel subunit of the complex, Tra1, an ATM/PI-3-kinase-related homolog of the human TRRAP cofactor, which is essential for c-Myc and E2F-mediated oncogenic transformation. Mass spectrometry, immunoblotting, and immunoprecipitation experiments confirm the stable association of this protein within SAGA. In addition, the Tra1 protein is a component of at least two other histone acetyltransferase protein complexes. These results indicate a role for Tra1 in the regulation of transcriptional activation through the recruitment of HAT activity to an activator-bound promoter.

Pubmed ID: 9885573

Authors

  • Grant PA
  • Schieltz D
  • Pray-Grant MG
  • Yates JR
  • Workman JL

Journal

Molecular cell

Publication Data

December 26, 1998

Associated Grants

  • Agency: PHS HHS, Id: 1182302

Mesh Terms

  • Acetyltransferases
  • Amino Acid Sequence
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Electrophoresis, Polyacrylamide Gel
  • Fungal Proteins
  • Histone Acetyltransferases
  • Immunoblotting
  • Molecular Sequence Data
  • Multienzyme Complexes
  • Protein Kinases
  • Protein-Serine-Threonine Kinases
  • Proteins
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Tumor Suppressor Proteins