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Dissecting the regulatory circuitry of a eukaryotic genome.

Genome-wide expression analysis was used to identify genes whose expression depends on the functions of key components of the transcription initiation machinery in yeast. Components of the RNA polymerase II holoenzyme, the general transcription factor TFIID, and the SAGA chromatin modification complex were found to have roles in expression of distinct sets of genes. The results reveal an unanticipated level of regulation which is superimposed on that due to gene-specific transcription factors, a novel mechanism for coordinate regulation of specific sets of genes when cells encounter limiting nutrients, and evidence that the ultimate targets of signal transduction pathways can be identified within the initiation apparatus.

Pubmed ID: 9845373


  • Holstege FC
  • Jennings EG
  • Wyrick JJ
  • Lee TI
  • Hengartner CJ
  • Green MR
  • Golub TR
  • Lander ES
  • Young RA



Publication Data

November 25, 1998

Associated Grants


Mesh Terms

  • Acetyltransferases
  • Chromatin
  • Cyclin-Dependent Kinase 8
  • Cyclin-Dependent Kinases
  • DNA-Binding Proteins
  • Eukaryotic Cells
  • Fungal Proteins
  • Gene Expression Regulation, Fungal
  • Genes, Regulator
  • Genes, cdc
  • Genome, Fungal
  • Histone Acetyltransferases
  • Mediator Complex
  • Nuclear Proteins
  • Protein Kinases
  • RNA Polymerase II
  • Saccharomyces cerevisiae Proteins
  • Signal Transduction
  • Transcription Factor TFIID
  • Transcription Factors
  • Transcription Factors, TFII
  • Transcription, Genetic