Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Dissecting the regulatory circuitry of a eukaryotic genome.

Cell | Nov 25, 1998

Genome-wide expression analysis was used to identify genes whose expression depends on the functions of key components of the transcription initiation machinery in yeast. Components of the RNA polymerase II holoenzyme, the general transcription factor TFIID, and the SAGA chromatin modification complex were found to have roles in expression of distinct sets of genes. The results reveal an unanticipated level of regulation which is superimposed on that due to gene-specific transcription factors, a novel mechanism for coordinate regulation of specific sets of genes when cells encounter limiting nutrients, and evidence that the ultimate targets of signal transduction pathways can be identified within the initiation apparatus.

Pubmed ID: 9845373 RIS Download

Mesh terms: Acetyltransferases | Chromatin | Cyclin-Dependent Kinase 8 | Cyclin-Dependent Kinases | DNA-Binding Proteins | Eukaryotic Cells | Fungal Proteins | Gene Expression Regulation, Fungal | Genes, Regulator | Genes, cdc | Genome, Fungal | Histone Acetyltransferases | Mediator Complex | Nuclear Proteins | Protein Kinases | RNA Polymerase II | Saccharomyces cerevisiae Proteins | Signal Transduction | Transcription Factor TFIID | Transcription Factors | Transcription Factors, TFII | Transcription, Genetic

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.