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Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation.

An intracellular protein termed CD2 binding protein 2 (CD2BP2), which binds to a site containing two PPPGHR segments within the cytoplasmic region of CD2, was identified. Mutagenesis and NMR analysis demonstrated that the CD2 binding region of CD2BP2 includes a 17-aa motif (GPY[orF]xxxxM[orV]xxWxxx GYF), also found in several yeast and Caenorhabditis elegans proteins of unknown function. In Jurkat T cells, over-expression of the isolated CD2BP2 domain binding to CD2 enhances the production of interleukin 2 on crosslinking of CD2 but not the T cell receptor. Hence, a proline-binding module distinct from SH3 and WW domains regulates protein-protein interactions.

Pubmed ID: 9843987 RIS Download

Mesh terms: Adaptor Proteins, Signal Transducing | Amino Acid Sequence | Animals | Antigens, CD2 | Base Sequence | Binding Sites | Caenorhabditis elegans | Carrier Proteins | DNA Mutational Analysis | Humans | Lymphocyte Activation | Molecular Sequence Data | Proline | Saccharomyces cerevisiae | Sequence Analysis | T-Lymphocytes

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Associated grants

  • Agency: NIAID NIH HHS, Id: R01 AI021226
  • Agency: NIAID NIH HHS, Id: AI21226
  • Agency: NIAID NIH HHS, Id: AI27581

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