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Aiolos regulates B cell activation and maturation to effector state.

Aiolos encodes a zinc finger DNA-binding protein that is highly expressed in mature B cells and is homologous to Ikaros. In the periphery of mice homozygous for an Aiolos-null mutation, B cells exhibit an activated cell surface phenotype and undergo augmented antigen receptor (BCR)-mediated in vitro proliferative responses, even at limiting amounts of stimulant. In vivo, T cell-dependent B cell responses, including the formation of germinal centers and elevated serum IgG and IgE, are detected in Aiolos-deficient mice in the absence of immunization. Auto-antibodies and development of B cell lymphomas are frequently seen among aging Aiolos mutants. In sharp contrast to conventional B cells, B cells of the peritoneum, of the marginal zone, and the recirculating bone marrow population are greatly reduced.

Pubmed ID: 9806640

Authors

  • Wang JH
  • Avitahl N
  • Cariappa A
  • Friedrich C
  • Ikeda T
  • Renold A
  • Andrikopoulos K
  • Liang L
  • Pillai S
  • Morgan BA
  • Georgopoulos K

Journal

Immunity

Publication Data

October 18, 1998

Associated Grants

  • Agency: NIAID NIH HHS, Id: R01 AI42254-01A1

Mesh Terms

  • Animals
  • Autoantibodies
  • B-Lymphocytes
  • Base Sequence
  • Cell Differentiation
  • Cytokines
  • DNA Primers
  • DNA-Binding Proteins
  • Hematopoietic Stem Cells
  • Ikaros Transcription Factor
  • Immunoglobulins
  • In Vitro Techniques
  • Lymphocyte Activation
  • Lymphoma, B-Cell
  • Macromolecular Substances
  • Mice
  • Mice, Knockout
  • Phenotype
  • T-Lymphocytes
  • Trans-Activators
  • Transcription Factors
  • Zinc Fingers