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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.

Cell | Oct 2, 1998

PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. mPTEN-mutant mouse embryos display regions of increased proliferation. In contrast, mPTEN-deficient immortalized mouse embryonic fibroblasts exhibit decreased sensitivity to cell death in response to a number of apoptotic stimuli, accompanied by constitutively elevated activity and phosphorylation of protein kinase B/Akt, a crucial regulator of cell survival. Expression of exogenous PTEN in mutant cells restores both their sensitivity to agonist-induced apoptosis and normal pattern of PKB/Akt phosphorylation. Furthermore, PTEN negatively regulates intracellular levels of phosphatidylinositol (3,4,5) trisphosphate in cells and dephosphorylates it in vitro. Our results show that PTEN may exert its role as a tumor suppressor by negatively regulating the PI3'K/PKB/Akt signaling pathway.

Pubmed ID: 9778245 RIS Download

Mesh terms: Animals | Apoptosis | Cell Division | Cell Survival | Cells, Cultured | Female | Fibroblasts | Genes, Tumor Suppressor | Mice | Mutagenesis | PTEN Phosphohydrolase | Phosphatidylinositol Phosphates | Phosphoric Monoester Hydrolases | Protein Tyrosine Phosphatases | Protein-Serine-Threonine Kinases | Proto-Oncogene Proteins | Proto-Oncogene Proteins c-akt | Substrate Specificity | Tumor Suppressor Proteins

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