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Two modes of survival of fission yeast without telomerase.

Deletion of the telomerase catalytic subunit gene trt1+ in Schizosaccharomyces pombe results in death for the majority of cells, but a subpopulation survives. Here it is shown that most survivors have circularized all of their chromosomes, whereas a smaller number maintain their telomeres presumably through recombination. When the telomeric DNA-binding gene taz1+ is also deleted, trt1- taz1- survivors use the recombinational mode more frequently. Moreover, the massive elongation of telomeres in taz1- cells is absent in the double mutant. Thus, Taz1p appears to regulate telomeric recombination as well as telomerase activity in fission yeast.

Pubmed ID: 9774280


  • Nakamura TM
  • Cooper JP
  • Cech TR


Science (New York, N.Y.)

Publication Data

October 16, 1998

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM28039

Mesh Terms

  • Chromosomes, Fungal
  • DNA Probes
  • DNA, Fungal
  • DNA-Binding Proteins
  • Gene Deletion
  • Genes, Fungal
  • Proteins
  • RNA
  • Recombination, Genetic
  • Schizosaccharomyces
  • Schizosaccharomyces pombe Proteins
  • Telomerase
  • Telomere
  • Telomere-Binding Proteins