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Two modes of survival of fission yeast without telomerase.

Science (New York, N.Y.) | Oct 16, 1998

http://www.ncbi.nlm.nih.gov/pubmed/9774280

Deletion of the telomerase catalytic subunit gene trt1+ in Schizosaccharomyces pombe results in death for the majority of cells, but a subpopulation survives. Here it is shown that most survivors have circularized all of their chromosomes, whereas a smaller number maintain their telomeres presumably through recombination. When the telomeric DNA-binding gene taz1+ is also deleted, trt1- taz1- survivors use the recombinational mode more frequently. Moreover, the massive elongation of telomeres in taz1- cells is absent in the double mutant. Thus, Taz1p appears to regulate telomeric recombination as well as telomerase activity in fission yeast.

Pubmed ID: 9774280 RIS Download

Mesh terms: Chromosomes, Fungal | DNA Probes | DNA, Fungal | DNA-Binding Proteins | Gene Deletion | Genes, Fungal | Proteins | RNA | Recombination, Genetic | Schizosaccharomyces | Schizosaccharomyces pombe Proteins | Telomerase | Telomere | Telomere-Binding Proteins

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM28039

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