• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest.

Mest (also known as Peg1), an imprinted gene expressed only from the paternal allele during development, was disrupted by gene targeting in embryonic stem (ES) cells. The targeted mutation is imprinted and reversibly silenced by passage through the female germ line. Paternal transmission activates the targeted allele and causes embryonic growth retardation associated with reduced postnatal survival rates in mutant progeny. More significantly, Mest-deficient females show abnormal maternal behaviour and impaired placentophagia, a distinctive mammalian behaviour. Our results provide evidence for the involvement of an imprinted gene in the control of adult behaviour.

Pubmed ID: 9771709

Authors

  • Lefebvre L
  • Viville S
  • Barton SC
  • Ishino F
  • Keverne EB
  • Surani MA

Journal

Nature genetics

Publication Data

October 28, 1998

Associated Grants

  • Agency: Wellcome Trust, Id:

Mesh Terms

  • Adult
  • Alleles
  • Animals
  • Female
  • Fetal Growth Retardation
  • Gene Targeting
  • Genomic Imprinting
  • Humans
  • Male
  • Maternal Behavior
  • Mice
  • Molecular Sequence Data
  • Pedigree
  • Phenotype
  • Proteins
  • RNA, Messenger