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Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors.

The recognition of HLA-C molecules by specific inhibitory receptors is a crucial step in the regulation of natural killer (NK) cell function. Using soluble, recombinant HLA-C molecules and NK inhibitory receptors (NKIR, members of the immunoglobulin superfamily), we show that HLA-C binds to NKIR molecules with extremely fast association and dissociation rates, among the fastest of the immune system interactions so far studied. These kinetics may be essential for the biological function of NK cells, i.e., to facilitate the rapid immunosurveillance of cells for absent or diminished expression of class I MHC proteins.

Pubmed ID: 9768753

Authors

  • Valés-Gómez M
  • Reyburn HT
  • Mandelboim M
  • Strominger JL

Journal

Immunity

Publication Data

September 28, 1998

Associated Grants

  • Agency: NCI NIH HHS, Id: CA-4774

Mesh Terms

  • Biosensing Techniques
  • HLA-C Antigens
  • Killer Cells, Natural
  • Kinetics
  • Ligands
  • Receptors, Immunologic
  • Receptors, KIR
  • Recombinant Proteins
  • Solubility
  • Temperature