• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy.

To better understand the dynamics of hepatitis C virus and the antiviral effect of interferon-alpha-2b (IFN), viral decline in 23 patients during therapy was analyzed with a mathematical model. The analysis indicates that the major initial effect of IFN is to block virion production or release, with blocking efficacies of 81, 95, and 96% for daily doses of 5, 10, and 15 million international units, respectively. The estimated virion half-life (t1/2) was, on average, 2.7 hours, with pretreatment production and clearance of 10(12) virions per day. The estimated infected cell death rate exhibited large interpatient variation (corresponding t1/2 = 1.7 to 70 days), was inversely correlated with baseline viral load, and was positively correlated with alanine aminotransferase levels. Fast death rates were predictive of virus being undetectable by polymerase chain reaction at 3 months. These findings show that infection with hepatitis C virus is highly dynamic and that early monitoring of viral load can help guide therapy.

Pubmed ID: 9756471


  • Neumann AU
  • Lam NP
  • Dahari H
  • Gretch DR
  • Wiley TE
  • Layden TJ
  • Perelson AS


Science (New York, N.Y.)

Publication Data

October 2, 1998

Associated Grants

  • Agency: NIDDK NIH HHS, Id: A1/DK41320-2
  • Agency: PHS HHS, Id: A139049-2
  • Agency: NCRR NIH HHS, Id: RR06555

Mesh Terms

  • Alanine Transaminase
  • Antiviral Agents
  • Cell Death
  • Dose-Response Relationship, Drug
  • Half-Life
  • Hepacivirus
  • Hepatitis C
  • Humans
  • Interferon-alpha
  • Kinetics
  • Models, Biological
  • RNA, Viral
  • Recombinant Proteins
  • Regression Analysis
  • Viral Load
  • Viremia
  • Virion
  • Virus Replication