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Ace2p, a regulator of CTS1 (chitinase) expression, affects pseudohyphal production in Saccharomyces cerevisiae.

Some diploid strains of Saccharomyces cerevisiae can grow both as a spherical yeast form and as a filamentous pseudohyphal form. Most yeasts capable of forming pseudohyphae possess a functional FLO8 gene. We show that disrupting the ACE2 transcription factor results in the production of pseudohyphae in a flo8-1 background. Disrupting the CTS1 (chitinase) gene also produces pseudohyphal growth in this background, but at a reduced level. Invasion of solid media by haploid and diploid cells is increased in ACE2 disruptions, but the diploids adhere poorly to the agar. Sigma1278b-derived strains, which generally produce pseudohyphae, have about 30-fold lower chitinase activity than other strains.

Pubmed ID: 9745020


  • King L
  • Butler G


Current genetics

Publication Data

September 16, 1998

Associated Grants

  • Agency: Wellcome Trust, Id:

Mesh Terms

  • Cell Adhesion
  • Chitin
  • Chitinase
  • DNA-Binding Proteins
  • Fungal Proteins
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Fungal
  • Genes, Fungal
  • Mutation
  • Nuclear Proteins
  • Ploidies
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators
  • Transcription Factors