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Ace2p, a regulator of CTS1 (chitinase) expression, affects pseudohyphal production in Saccharomyces cerevisiae.

Current genetics | Sep 16, 1998

http://www.ncbi.nlm.nih.gov/pubmed/9745020

Some diploid strains of Saccharomyces cerevisiae can grow both as a spherical yeast form and as a filamentous pseudohyphal form. Most yeasts capable of forming pseudohyphae possess a functional FLO8 gene. We show that disrupting the ACE2 transcription factor results in the production of pseudohyphae in a flo8-1 background. Disrupting the CTS1 (chitinase) gene also produces pseudohyphal growth in this background, but at a reduced level. Invasion of solid media by haploid and diploid cells is increased in ACE2 disruptions, but the diploids adhere poorly to the agar. Sigma1278b-derived strains, which generally produce pseudohyphae, have about 30-fold lower chitinase activity than other strains.

Pubmed ID: 9745020 RIS Download

Mesh terms: Cell Adhesion | Chitin | Chitinase | DNA-Binding Proteins | Fungal Proteins | Gene Expression Regulation, Developmental | Gene Expression Regulation, Fungal | Genes, Fungal | Mutation | Nuclear Proteins | Ploidies | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Trans-Activators | Transcription Factors

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