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Fertilization defects in sperm from mice lacking fertilin beta.

Science (New York, N.Y.) | Sep 18, 1998

Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm. Sperm from mice lacking fertilin beta were shown to be deficient in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus into the oviduct, and binding to the egg zona pellucida. Egg activation was unaffected. The results are consistent with a direct role of fertilin in sperm-egg plasma membrane interaction. Fertilin could also have a direct role in sperm-zona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis.

Pubmed ID: 9743500 RIS Download

Mesh terms: ADAM Proteins | Animals | Calcium | Cell Adhesion | Cell Membrane | Fallopian Tubes | Female | Fertilins | Male | Membrane Fusion | Membrane Glycoproteins | Metalloendopeptidases | Mice | Mice, Inbred C57BL | Mice, Knockout | Ovum | Sperm Capacitation | Sperm-Ovum Interactions | Spermatogenesis | Spermatozoa | Zona Pellucida

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Associated grants

  • Agency: NICHD NIH HHS, Id: HD16580
  • Agency: NICHD NIH HHS, Id: U54HD29125

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