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Fertilization defects in sperm from mice lacking fertilin beta.

Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm. Sperm from mice lacking fertilin beta were shown to be deficient in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus into the oviduct, and binding to the egg zona pellucida. Egg activation was unaffected. The results are consistent with a direct role of fertilin in sperm-egg plasma membrane interaction. Fertilin could also have a direct role in sperm-zona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis.

Pubmed ID: 9743500

Authors

  • Cho C
  • Bunch DO
  • Faure JE
  • Goulding EH
  • Eddy EM
  • Primakoff P
  • Myles DG

Journal

Science (New York, N.Y.)

Publication Data

September 18, 1998

Associated Grants

  • Agency: NICHD NIH HHS, Id: HD16580
  • Agency: NICHD NIH HHS, Id: U54HD29125

Mesh Terms

  • ADAM Proteins
  • Animals
  • Calcium
  • Cell Adhesion
  • Cell Membrane
  • Fallopian Tubes
  • Female
  • Male
  • Membrane Fusion
  • Membrane Glycoproteins
  • Metalloendopeptidases
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Ovum
  • Sperm Capacitation
  • Sperm-Ovum Interactions
  • Spermatogenesis
  • Spermatozoa
  • Zona Pellucida