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JOY: protein sequence-structure representation and analysis.

MOTIVATION: JOY is a program to annotate protein sequence alignments with three-dimensional (3D) structural features. It was developed to display 3D structural information in a sequence alignment and to help understand the conservation of amino acids in their specific local environments. RESULTS: : The JOY representation now constitutes an essential part of the two databases of protein structure alignments: HOMSTRAD (http://www-cryst.bioc.cam.ac.uk/homstrad ) and CAMPASS (http://www-cryst.bioc.cam.ac. uk/campass). It has also been successfully used for identifying distant evolutionary relationships. AVAILABILITY: The program can be obtained via anonymous ftp from torsa.bioc.cam.ac.uk from the directory /pub/joy/. The address for the JOY server is http://www-cryst.bioc.cam.ac.uk/cgi-bin/joy.cgi. CONTACT: kenji@cryst.bioc.cam.ac.uk

Pubmed ID: 9730927


  • Mizuguchi K
  • Deane CM
  • Blundell TL
  • Johnson MS
  • Overington JP


Bioinformatics (Oxford, England)

Publication Data

November 3, 1998

Associated Grants


Mesh Terms

  • Amino Acid Sequence
  • Hydrogen Bonding
  • Molecular Sequence Data
  • Protein Conformation
  • Protein Structure, Secondary
  • Proteins
  • Sequence Alignment
  • Software