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Increased anxiety of mice lacking the serotonin1A receptor.

Brain serotonin (5-HT) has been implicated in a number of physiological processes and pathological conditions. These effects are mediated by at least 14 different 5-HT receptors. We have inactivated the gene encoding the 5-HT1A receptor in mice and found that receptor-deficient animals have an increased tendency to avoid a novel and fearful environment and to escape a stressful situation, behaviors consistent with an increased anxiety and stress response. Based on the role of the 5-HT1A receptor in the feedback regulation of the 5-HT system, we hypothesize that an increased serotonergic neurotransmission is responsible for the anxiety-like behavior of receptor-deficient animals. This view is consistent with earlier studies showing that pharmacological activation of the 5-HT system is anxiogenic in animal models and also in humans.

Pubmed ID: 9724773


  • Parks CL
  • Robinson PS
  • Sibille E
  • Shenk T
  • Toth M


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

September 1, 1998

Associated Grants


Mesh Terms

  • Animals
  • Anxiety
  • Base Sequence
  • Behavior, Animal
  • Brain
  • DNA Primers
  • Female
  • Genotype
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1