Increased anxiety of mice lacking the serotonin1A receptor.
Brain serotonin (5-HT) has been implicated in a number of physiological processes and pathological conditions. These effects are mediated by at least 14 different 5-HT receptors. We have inactivated the gene encoding the 5-HT1A receptor in mice and found that receptor-deficient animals have an increased tendency to avoid a novel and fearful environment and to escape a stressful situation, behaviors consistent with an increased anxiety and stress response. Based on the role of the 5-HT1A receptor in the feedback regulation of the 5-HT system, we hypothesize that an increased serotonergic neurotransmission is responsible for the anxiety-like behavior of receptor-deficient animals. This view is consistent with earlier studies showing that pharmacological activation of the 5-HT system is anxiogenic in animal models and also in humans.
Pubmed ID: 9724773 RIS Download
Animals | Anxiety | Base Sequence | Behavior, Animal | Brain | DNA Primers | Female | Genotype | Male | Mice | Mice, Inbred BALB C | Mice, Knockout | Receptors, Serotonin | Receptors, Serotonin, 5-HT1