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DARPP-32: regulator of the efficacy of dopaminergic neurotransmission.

Science (New York, N.Y.) | Aug 7, 1998

http://www.ncbi.nlm.nih.gov/pubmed/9694658

Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.

Pubmed ID: 9694658 RIS Download

Mesh terms: Amphetamines | Animals | Behavior, Animal | Calcium | Cocaine | Corpus Striatum | Cyclic AMP-Dependent Protein Kinases | Dopamine | Dopamine Agents | Dopamine and cAMP-Regulated Phosphoprotein 32 | Female | Gene Expression Regulation | Gene Targeting | Genes, fos | Glutamic Acid | Male | Mice | Mice, Inbred C57BL | Nerve Tissue Proteins | Neurons | Phosphoprotein Phosphatases | Phosphoproteins | Phosphorylation | Raclopride | Receptors, Dopamine D1 | Receptors, N-Methyl-D-Aspartate | Salicylamides | Sodium-Potassium-Exchanging ATPase | Synaptic Transmission | gamma-Aminobutyric Acid

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Associated grants

  • Agency: NIDA NIH HHS, Id: DA 08227
  • Agency: NIDA NIH HHS, Id: DA10044
  • Agency: NIDA NIH HHS, Id: F31 DA005794
  • Agency: NIMH NIH HHS, Id: MH40899

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