Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Nucleation of COPII vesicular coat complex by endoplasmic reticulum to Golgi vesicle SNAREs.

Science (New York, N.Y.) | Jul 31, 1998

http://www.ncbi.nlm.nih.gov/pubmed/9685263

Protein trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus involves specific uptake into coat protein complex II (COPII)-coated vesicles of secretory and of vesicle targeting (v-SNARE) proteins. Here, two ER to Golgi v-SNAREs, Bet1p and Bos1p, were shown to interact specifically with Sar1p, Sec23p, and Sec24p, components of the COPII coat, in a guanine nucleotide-dependent fashion. Other v-SNAREs, Sec22p and Ykt6p, might interact more weakly with the COPII coat or interact indirectly by binding to Bet1p or Bos1p. The data suggest that transmembrane proteins can be taken up into COPII vesicles by direct interactions with the coat proteins and may play a structural role in the assembly of the COPII coat complex.

Pubmed ID: 9685263 RIS Download

Mesh terms: Binding Sites | COP-Coated Vesicles | Carrier Proteins | Endoplasmic Reticulum | Fungal Proteins | GTP Phosphohydrolases | GTP-Binding Proteins | GTPase-Activating Proteins | Golgi Apparatus | Guanosine Diphosphate | Guanosine Triphosphate | Guanylyl Imidodiphosphate | Membrane Proteins | Membrane Transport Proteins | Monomeric GTP-Binding Proteins | Qb-SNARE Proteins | Qc-SNARE Proteins | R-SNARE Proteins | Receptors, Cell Surface | Recombinant Fusion Proteins | SNARE Proteins | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Vesicular Transport Proteins

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.