Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development.

Neuron | Jun 24, 1998

http://www.ncbi.nlm.nih.gov/pubmed/9655498

Corticotropin releasing factor (CRF) is a major integrator of adaptive responses to stress. Two biochemically and pharmacologically distinct CRF receptor subtypes (CRFR1 and CRFR2) have been described. We have generated mice null for the CRFR1 gene to elucidate the specific developmental and physiological roles of CRF receptor mediated pathways. Behavioral analyses revealed that mice lacking CRFR1 displayed markedly reduced anxiety. Mutant mice also failed to exhibit the characteristic hormonal response to stress due to a disruption of the hypothalamic-pituitary-adrenal (HPA) axis. Homozygous mutant mice derived from crossing heterozygotes displayed low plasma corticosterone concentrations resulting from a marked agenesis of the zona fasciculata region of the adrenal gland. The offspring from homozygote crosses died within 48 hr after birth due to a pronounced lung dysplasia. The adrenal agenesis in mutant animals was attributed to insufficient adrenocorticotropic hormone (ACTH) production during the neonatal period and was rescued by ACTH replacement. These results suggest that CRFR1 plays an important role both in the development of a functional HPA axis and in mediating behavioral changes associated with anxiety.

Pubmed ID: 9655498 RIS Download

Mesh terms: Adaptation, Physiological | Adrenal Gland Diseases | Adrenal Glands | Adrenocorticotropic Hormone | Animals | Anxiety | Behavior, Animal | Chimera | Corticosterone | Female | Gene Expression Regulation, Developmental | Homozygote | Male | Maze Learning | Mice | Mice, Inbred C57BL | Mice, Neurologic Mutants | Mutation | Neurosecretory Systems | Paraventricular Hypothalamic Nucleus | Pituitary Gland | Receptors, Corticotropin-Releasing Hormone | Stress, Physiological | Survival Analysis

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIDDK NIH HHS, Id: DK-26741
  • Agency: NIDDK NIH HHS, Id: DK09551

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.