Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney.
Morphogenesis of the insect kidney, the Malpighian tubules, is controlled in Drosophila by a single large cell, the tip cell. It has been postulated that this cell sends out a mitogenic signal that induces the division of neighboring cells. The signal and the molecules that receive it have remained elusive. We show that the COUP-TF-related nuclear orphan receptor Seven-up is a key component that becomes induced in response to mitogenic EGF receptor signaling activity emanating from the tip cell. Seven-up in turn is capable of regulating the transcription of cell cycle regulators.
Pubmed ID: 9637680 RIS Download
Animals | COUP Transcription Factor I | Cell Cycle | Cell Division | DNA-Binding Proteins | Drosophila | Eukaryotic Cells | Gene Expression | Gene Expression Regulation, Developmental | Genes, Insect | Insect Proteins | Malpighian Tubules | Mitogens | Receptor, Epidermal Growth Factor | Receptors, Cytoplasmic and Nuclear | Receptors, Steroid | Signal Transduction | Transcription Factors