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Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney.

Morphogenesis of the insect kidney, the Malpighian tubules, is controlled in Drosophila by a single large cell, the tip cell. It has been postulated that this cell sends out a mitogenic signal that induces the division of neighboring cells. The signal and the molecules that receive it have remained elusive. We show that the COUP-TF-related nuclear orphan receptor Seven-up is a key component that becomes induced in response to mitogenic EGF receptor signaling activity emanating from the tip cell. Seven-up in turn is capable of regulating the transcription of cell cycle regulators.

Pubmed ID: 9637680


  • Kerber B
  • Fellert S
  • Hoch M


Genes & development

Publication Data

June 15, 1998

Associated Grants


Mesh Terms

  • Animals
  • COUP Transcription Factor I
  • Cell Cycle
  • Cell Division
  • DNA-Binding Proteins
  • Drosophila
  • Eukaryotic Cells
  • Gene Expression
  • Gene Expression Regulation, Developmental
  • Genes, Insect
  • Insect Proteins
  • Malpighian Tubules
  • Mitogens
  • Receptor, Epidermal Growth Factor
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Steroid
  • Signal Transduction
  • Transcription Factors