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Human RanBP3, a group of nuclear RanGTP binding proteins.

A group of novel human Ran-binding proteins, RanBP3, was identified using the yeast two-hybrid system via Ran-mediated interaction with the nucleotide exchange factor RCC1. Several open reading frames, representing putative alternatively spliced products, were established by cDNA cloning. Two of them, RanBP3-a and RanBP3-b, encode nuclear hydrophilic proteins of 499 and 562 amino acid residues. The sequences contain FXFG motifs, characteristic of a subgroup of nucleoporins, and a C-terminal domain showing similarity to the Ran-binding protein RanBP1. These proteins are localized in the nucleus, preferentially bind RanGTP and may be nuclear effectors of the Ran pathway.

Pubmed ID: 9637251

Authors

  • Mueller L
  • Cordes VC
  • Bischoff FR
  • Ponstingl H

Journal

FEBS letters

Publication Data

May 15, 1998

Associated Grants

None

Mesh Terms

  • Alternative Splicing
  • Amino Acid Sequence
  • Carrier Proteins
  • Cell Cycle Proteins
  • Cell Nucleus
  • DNA-Binding Proteins
  • GTP-Binding Proteins
  • Guanine Nucleotide Exchange Factors
  • HeLa Cells
  • Humans
  • Molecular Sequence Data
  • Nuclear Proteins
  • Nucleocytoplasmic Transport Proteins
  • Recombinant Proteins
  • Sequence Homology, Amino Acid
  • Transcription, Genetic
  • Yeasts
  • ran GTP-Binding Protein