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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.
Pubmed ID: 9634230
Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A McLean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG
June 11, 1998
Agency: Intramural NIH HHS, Id: Z01 AI000783-11 Agency: Wellcome Trust, Id:
Chromosome Mapping Chromosomes, Bacterial Drug Resistance, Microbial Genome, Bacterial Humans Lipid Metabolism Molecular Sequence Data Mycobacterium tuberculosis Sequence Analysis, DNA Tuberculosis
Extradiol ring-cleavage dioxygenase: Involved in biphenyl-2,3-diol 1,2-dioxygenase activity PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE): Lipid transport and metabolism Inorganic polyphosphate/ATP-NAD kinase: Involved in NAD+ kinase activity Mycolic acid synthase: Involved in cyclopropane-fatty-acyl-phospholipid synthase activity Thymidylate kinase: Nucleotide transport and metabolism 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase: Lipid transport and metabolism Cytochrome P450 51: Secondary metabolites biosynthesis, transport and catabolism Cyclopropane-fatty-acyl-phospholipid synthase 2: Cell wall/membrane/envelope biogenesis Probable L-lysine-epsilon aminotransferase: Amino acid transport and metabolism Probable arabinosyltransferase A: Involved in transferase activity, transferring pentosyl groups Proteasome subunit beta: Posttranslational modification, protein turnover, chaperones Isocitrate lyase: Energy production and conversion Cell division protein ftsZ: Cell cycle control, cell division, chromosome partitioning Putative cytochrome P450 130: Secondary metabolites biosynthesis, transport and catabolism Peptide deformylase: Translation, ribosomal structure and biogenesis DNA-directed RNA polymerase beta' chain: Transcription PROBABLE NAPHTHOATE SYNTHASE MENB: Involved in catalytic activity Hypothetical protein: Involved in N-acetyltransferase activity UDP-galactopyranose mutase: Involved in oxidoreductase activity 3-oxoacyl-[acyl-carrier-protein] synthase 3: Lipid transport and metabolism Ribose-5-phosphate isomerase B: Carbohydrate transport and metabolism PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA: Involved in oxidoreductase activity Deoxyuridine 5'-triphosphate nucleotidohydrolase: Nucleotide transport and metabolism Enoyl-[acyl-carrier-protein] reductase [NADH]: Lipid transport and metabolism Pantoate--beta-alanine ligase: Coenzyme transport and metabolism Probable arabinosyltransferase C: Involved in transferase activity, transferring pentosyl groups TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN: Involved in DNA binding Shikimate kinase: Involved in shikimate kinase activity Guanylate kinase: Nucleotide transport and metabolism Hemoglobin-like protein HbO: Involved in oxygen binding Aminoglycoside 2'-N-acetyltransferase: Involved in N-acetyltransferase activity D-3-phosphoglycerate dehydrogenase: Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase: Coenzyme transport and metabolism Malate synthase G: Energy production and conversion 6,7-dimethyl-8-ribityllumazine synthase: Coenzyme transport and metabolism DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC: Involved in dTDP-4-dehydrorhamnose 3,5-epimerase activity Peroxidase/catalase T: Inorganic ion transport and metabolism PROBABLE LIGNIN PEROXIDASE LIPJ: Involved in phosphorus-oxygen lyase activity Dihydrofolate reductase: Coenzyme transport and metabolism 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE BPHD: Involved in hydrolase activity 2-isopropylmalate synthase: Amino acid transport and metabolism Hypothetical protein Rv0046c/MT0052: Involved in inositol-3-phosphate synthase activity HYPOTHETICAL EXPORTED PROTEIN Adenosylhomocysteinase: Coenzyme transport and metabolism Epoxide hydrolase: Involved in hydrolase activity Probable arabinosyltransferase B: Involved in transferase activity, transferring pentosyl groups Chorismate mutase-related protein: Amino acid transport and metabolism Probable serine/threonine-protein kinase pknB: Involved in penicillin binding Cytochrome P450 121: Secondary metabolites biosynthesis, transport and catabolism Uncharacterized protein Rv0948c/MT0975: Amino acid transport and metabolism