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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.
Pubmed ID: 9634230
Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A McLean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG
June 11, 1998
Agency: Intramural NIH HHS, Id: Z01 AI000783-11 Agency: Wellcome Trust, Id:
Chromosome Mapping Chromosomes, Bacterial Drug Resistance, Microbial Genome, Bacterial Humans Lipid Metabolism Molecular Sequence Data Mycobacterium tuberculosis Sequence Analysis, DNA Tuberculosis
PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE): Lipid transport and metabolism Inorganic polyphosphate/ATP-NAD kinase: Involved in NAD+ kinase activity Thymidylate kinase: Nucleotide transport and metabolism 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase: Lipid transport and metabolism Cyclopropane-fatty-acyl-phospholipid synthase 2: Cell wall/membrane/envelope biogenesis Probable arabinosyltransferase A: Involved in transferase activity, transferring pentosyl groups Proteasome subunit beta: Posttranslational modification, protein turnover, chaperones Isocitrate lyase: Energy production and conversion Putative cytochrome P450 130: Secondary metabolites biosynthesis, transport and catabolism UDP-galactopyranose mutase: Involved in oxidoreductase activity 3-oxoacyl-[acyl-carrier-protein] synthase 3: Lipid transport and metabolism Enoyl-[acyl-carrier-protein] reductase [NADH]: Lipid transport and metabolism Probable arabinosyltransferase C: Involved in transferase activity, transferring pentosyl groups TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN: Involved in DNA binding Shikimate kinase: Involved in shikimate kinase activity Aminoglycoside 2'-N-acetyltransferase: Involved in N-acetyltransferase activity D-3-phosphoglycerate dehydrogenase: Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC: Involved in dTDP-4-dehydrorhamnose 3,5-epimerase activity Peroxidase/catalase T: Inorganic ion transport and metabolism PROBABLE LIGNIN PEROXIDASE LIPJ: Involved in phosphorus-oxygen lyase activity HYPOTHETICAL EXPORTED PROTEIN Epoxide hydrolase: Involved in hydrolase activity Cytochrome P450 121: Secondary metabolites biosynthesis, transport and catabolism Uncharacterized protein Rv0948c/MT0975: Amino acid transport and metabolism 3-dehydroquinate dehydratase: Amino acid transport and metabolism Dihydrodipicolinate reductase: Amino acid transport and metabolism Short-chain Z-isoprenyl diphosphate synthetase: Lipid transport and metabolism Probable thiol peroxidase: Involved in oxidoreductase activity METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2: Involved in cyclopropane-fatty-acyl-phospholipid synthase activity Purine nucleoside phosphorylase: Nucleotide transport and metabolism Dihydropteroate synthase 1: Coenzyme transport and metabolism Guanylate kinase: Nucleotide transport and metabolism Hemoglobin-like protein HbO: Involved in oxygen binding 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase: Coenzyme transport and metabolism Malate synthase G: Energy production and conversion 6,7-dimethyl-8-ribityllumazine synthase: Coenzyme transport and metabolism Dihydrofolate reductase: Coenzyme transport and metabolism 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE BPHD: Involved in hydrolase activity 2-isopropylmalate synthase: Amino acid transport and metabolism Hypothetical protein Rv0046c/MT0052: Involved in inositol-3-phosphate synthase activity Adenosylhomocysteinase: Coenzyme transport and metabolism Probable arabinosyltransferase B: Involved in transferase activity, transferring pentosyl groups Probable serine/threonine-protein kinase pknB: Involved in penicillin binding Chorismate mutase-related protein: Amino acid transport and metabolism METHOXY MYCOLIC ACID SYNTHASE 4 MMAA4 (METHYL MYCOLIC ACID SYNTHASE 4) (MMA4) (HYDROXY MYCOLIC ACID SYNTHASE): Cell wall/membrane/envelope biogenesis Regulator of ribonuclease activity A: Coenzyme transport and metabolism Proteasome: Involved in threonine endopeptidase activity POSSIBLE CELLULASE CELA1: Involved in hydrolase activity, hydrolyzing O-glycosyl compounds Nicotinate-nucleotide pyrophosphorylase [carboxylating]: Coenzyme transport and metabolism