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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

Nature | Jun 11, 1998

http://www.ncbi.nlm.nih.gov/pubmed/9634230

Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.

Pubmed ID: 9634230 RIS Download

Mesh terms: Chromosome Mapping | Chromosomes, Bacterial | Drug Resistance, Microbial | Genome, Bacterial | Humans | Lipid Metabolism | Molecular Sequence Data | Mycobacterium tuberculosis | Sequence Analysis, DNA | Tuberculosis

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Associated grants

  • Agency: Intramural NIH HHS, Id: Z01 AI000783-11
  • Agency: Wellcome Trust, Id:

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