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Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity.

http://www.ncbi.nlm.nih.gov/pubmed/9632813

The gene coding for human cyclin K was isolated as a CPR (cell-cycle progression restoration) gene by virtue of its ability to impart a Far- phenotype to the budding yeast Saccharomyces cerevisiae and to rescue the lethality of a deletion of the G1 cyclin genes CLN1, CLN2, and CLN3. The cyclin K gene encodes a 357-amino-acid protein most closely related to human cyclins C and H, which have been proposed to play a role in regulating basal transcription through their association with and activation of cyclin-dependent kinases (Cdks) that phosphorylate the carboxyl-terminal domain (CTD) of the large subunit of RNA polymerase II (RNAP II). Murine and Drosophila melanogaster homologs of cyclin K have also been identified. Cyclin K mRNA is ubiquitously expressed in adult mouse and human tissues, but is most abundant in the developing germ cells of the adult testis and ovaries. Cyclin K is associated with potent CTD kinase and Cdk kinase (CAK) activity in vitro and coimmunoprecipitates with the large subunit of RNAP II. Thus, cyclin K represents a new member of the "transcription" cyclin family which may play a dual role in regulating Cdk and RNAP II activity.

Pubmed ID: 9632813 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Base Sequence | CDC2 Protein Kinase | Cell Line | Coenzymes | Cyclin-Dependent Kinase 8 | Cyclin-Dependent Kinases | Cyclins | Drosophila Proteins | Drosophila melanogaster | G1 Phase | Glutathione Transferase | Humans | Insects | Mice | Mice, Inbred C57BL | Molecular Sequence Data | Phenotype | Protein Kinases | Protein-Serine-Threonine Kinases | RNA Polymerase II | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Sequence Homology, Amino Acid | Ubiquitins

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM44664

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