Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.

Nature | May 28, 1998

Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles. Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we have called receptor-activity-modifying proteins or RAMPs, are expressed. RAMPs are required to transport CRLR to the plasma membrane. RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors.

Pubmed ID: 9620797 RIS Download

Mesh terms: 3T3 Cells | Adrenomedullin | Amino Acid Sequence | Animals | Biological Transport | Calcitonin | Calcitonin Gene-Related Peptide | Calcitonin Receptor-Like Protein | Cell Line | Cloning, Molecular | Cross-Linking Reagents | Cystic Fibrosis Transmembrane Conductance Regulator | Gene Expression | Glycosylation | Humans | Intracellular Signaling Peptides and Proteins | Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase | Membrane Proteins | Mice | Molecular Sequence Data | Peptides | RNA, Messenger | Receptor Activity-Modifying Protein 1 | Receptor Activity-Modifying Protein 2 | Receptor Activity-Modifying Proteins | Receptors, Adrenomedullin | Receptors, Calcitonin | Receptors, Calcitonin Gene-Related Peptide | Receptors, Peptide | Sequence Alignment | Tumor Cells, Cultured | Xenopus

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants


Gene Ontology (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.