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RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.

Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles. Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we have called receptor-activity-modifying proteins or RAMPs, are expressed. RAMPs are required to transport CRLR to the plasma membrane. RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors.

Pubmed ID: 9620797


  • McLatchie LM
  • Fraser NJ
  • Main MJ
  • Wise A
  • Brown J
  • Thompson N
  • Solari R
  • Lee MG
  • Foord SM



Publication Data

May 28, 1998

Associated Grants


Mesh Terms

  • 3T3 Cells
  • Adrenomedullin
  • Amino Acid Sequence
  • Animals
  • Biological Transport
  • Calcitonin
  • Calcitonin Gene-Related Peptide
  • Calcitonin Receptor-Like Protein
  • Cell Line
  • Cloning, Molecular
  • Cross-Linking Reagents
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Gene Expression
  • Glycosylation
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase
  • Membrane Proteins
  • Mice
  • Molecular Sequence Data
  • Peptides
  • RNA, Messenger
  • Receptor Activity-Modifying Protein 1
  • Receptor Activity-Modifying Protein 2
  • Receptor Activity-Modifying Proteins
  • Receptors, Adrenomedullin
  • Receptors, Calcitonin
  • Receptors, Calcitonin Gene-Related Peptide
  • Receptors, Peptide
  • Sequence Alignment
  • Tumor Cells, Cultured
  • Xenopus