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Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR).

FEBS letters | May 1, 1998

The Na+-H+ exchanger regulatory factor (NHE-RF) is a cytoplasmic phosphoprotein that was first found to be involved in protein kinase A mediated regulation of ion transport. NHE-RF contains two distinct protein interaction PDZ domains: NHE-RF-PDZ1 and NHE-RF-PDZ2. However, their binding partners are currently unknown. Because PDZ domains usually bind to specific short linear C-terminal sequences, we have carried out affinity selection of random peptides for specific sequences that interact with the NHE-RF PDZ domains and found that NHE-RF-PDZ1 is capable of binding to the CFTR C-terminus. The specific and tight association suggests a potential regulatory role of NHE-RF in cystic fibrosis transmembrane conductance regulator (CFTR) function.

Pubmed ID: 9613608 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Consensus Sequence | Cystic Fibrosis Transmembrane Conductance Regulator | Drosophila Proteins | Insect Proteins | Mice | Molecular Sequence Data | Phosphoproteins | Protein Conformation | Sequence Alignment | Sequence Homology, Amino Acid | Sodium-Hydrogen Antiporter

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Mouse Genome Informatics (Data, Gene Annotation)

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