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Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses.

A role for the Fc receptor beta chain (FcRbeta) in the pathogenesis of allergy has been suggested by genetic studies. FcRbeta is a subunit common to the high-affinity IgE (FcepsilonRI) and low-affinity IgG (FcgammaRIII) receptors, both of which contribute to the initiation of allergic reactions. Current in vitro data suggest that FcRbeta can function as either a positive or negative regulator, leaving a mechanistic explanation for its association with the development of atopy unclear. To address this controversy, we have generated novel mouse models relevant to human Fc receptor function. Analysis of FcepsilonRI- and FcgammaRIII-dependent responses in these mice provides unequivocal genetic evidence that FcRbeta functions as an amplifier of early and late mast cell responses and, remarkably, in vivo anaphylactic responses.

Pubmed ID: 9586641

Authors

  • Dombrowicz D
  • Lin S
  • Flamand V
  • Brini AT
  • Koller BH
  • Kinet JP

Journal

Immunity

Publication Data

April 26, 1998

Associated Grants

None

Mesh Terms

  • Anaphylaxis
  • Animals
  • Calcium
  • Cell Degranulation
  • Humans
  • Hypersensitivity
  • Immunoglobulin E
  • Immunoglobulin G
  • In Vitro Techniques
  • Interleukin-6
  • Mast Cells
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Mice, Transgenic
  • Models, Biological
  • Phosphorylation
  • Receptors, IgE
  • Receptors, IgG
  • Signal Transduction