Literature search services are currently unavailable. During our hosting provider's UPS upgrade we experienced a hardware failure and are currently working to resolve the issue.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses.

A role for the Fc receptor beta chain (FcRbeta) in the pathogenesis of allergy has been suggested by genetic studies. FcRbeta is a subunit common to the high-affinity IgE (FcepsilonRI) and low-affinity IgG (FcgammaRIII) receptors, both of which contribute to the initiation of allergic reactions. Current in vitro data suggest that FcRbeta can function as either a positive or negative regulator, leaving a mechanistic explanation for its association with the development of atopy unclear. To address this controversy, we have generated novel mouse models relevant to human Fc receptor function. Analysis of FcepsilonRI- and FcgammaRIII-dependent responses in these mice provides unequivocal genetic evidence that FcRbeta functions as an amplifier of early and late mast cell responses and, remarkably, in vivo anaphylactic responses.

Pubmed ID: 9586641


  • Dombrowicz D
  • Lin S
  • Flamand V
  • Brini AT
  • Koller BH
  • Kinet JP



Publication Data

April 26, 1998

Associated Grants


Mesh Terms

  • Anaphylaxis
  • Animals
  • Calcium
  • Cell Degranulation
  • Humans
  • Hypersensitivity
  • Immunoglobulin E
  • Immunoglobulin G
  • In Vitro Techniques
  • Interleukin-6
  • Mast Cells
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Mice, Transgenic
  • Models, Biological
  • Phosphorylation
  • Receptors, IgE
  • Receptors, IgG
  • Signal Transduction