Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses.
A role for the Fc receptor beta chain (FcRbeta) in the pathogenesis of allergy has been suggested by genetic studies. FcRbeta is a subunit common to the high-affinity IgE (FcepsilonRI) and low-affinity IgG (FcgammaRIII) receptors, both of which contribute to the initiation of allergic reactions. Current in vitro data suggest that FcRbeta can function as either a positive or negative regulator, leaving a mechanistic explanation for its association with the development of atopy unclear. To address this controversy, we have generated novel mouse models relevant to human Fc receptor function. Analysis of FcepsilonRI- and FcgammaRIII-dependent responses in these mice provides unequivocal genetic evidence that FcRbeta functions as an amplifier of early and late mast cell responses and, remarkably, in vivo anaphylactic responses.
Pubmed ID: 9586641 RIS Download
Anaphylaxis | Animals | Calcium | Cell Degranulation | Humans | Hypersensitivity | Immunoglobulin E | Immunoglobulin G | In Vitro Techniques | Interleukin-6 | Mast Cells | Mice | Mice, Inbred BALB C | Mice, Knockout | Mice, Transgenic | Models, Biological | Phosphorylation | Receptors, IgE | Receptors, IgG | Signal Transduction