Our hosting provider will be performing UPS maintenance on Tuesday, Oct 25, 2016 between 8 AM and 5 PM PDT. SciCrunch searching services will be down during this time.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Knowing where and getting there: a human navigation network.


The neural basis of navigation by humans was investigated with functional neuroimaging of brain activity during navigation in a familiar, yet complex virtual reality town. Activation of the right hippocampus was strongly associated with knowing accurately where places were located and navigating accurately between them. Getting to those places quickly was strongly associated with activation of the right caudate nucleus. These two right-side brain structures function in the context of associated activity in right inferior parietal and bilateral medial parietal regions that support egocentric movement through the virtual town, and activity in other left-side regions (hippocampus, frontal cortex) probably involved in nonspatial aspects of navigation. These findings outline a network of brain areas that support navigation in humans and link the functions of these regions to physiological observations in other mammals.

Pubmed ID: 9572740


  • Maguire EA
  • Burgess N
  • Donnett JG
  • Frackowiak RS
  • Frith CD
  • O'Keefe J


Science (New York, N.Y.)

Publication Data

May 8, 1998

Associated Grants

  • Agency: Wellcome Trust, Id:

Mesh Terms

  • Brain Mapping
  • Caudate Nucleus
  • Cues
  • Frontal Lobe
  • Hippocampus
  • Humans
  • Male
  • Memory
  • Neural Pathways
  • Orientation
  • Parietal Lobe
  • Psychomotor Performance
  • Regional Blood Flow
  • Space Perception
  • Tomography, Emission-Computed