We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.

Cell | Apr 17, 1998

In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic response characterized by increased myocardial cell size and activation of fetal cardiac genes. We show that cardiac hypertrophy is induced by the calcium-dependent phosphatase calcineurin, which dephosphorylates the transcription factor NF-AT3, enabling it to translocate to the nucleus. NF-AT3 interacts with the cardiac zinc finger transcription factor GATA4, resulting in synergistic activation of cardiac transcription. Transgenic mice that express activated forms of calcineurin or NF-AT3 in the heart develop cardiac hypertrophy and heart failure that mimic human heart disease. Pharmacologic inhibition of calcineurin activity blocks hypertrophy in vivo and in vitro. These results define a novel hypertrophic signaling pathway and suggest pharmacologic approaches to prevent cardiac hypertrophy and heart failure.

Pubmed ID: 9568714 RIS Download

Mesh terms: Angiotensin II | Animals | Animals, Newborn | Atrial Natriuretic Factor | Calcineurin | Cardiomegaly | Cell Nucleus | DNA-Binding Proteins | GATA4 Transcription Factor | Immunosuppressive Agents | Mice | Mice, Transgenic | Myocardium | NFATC Transcription Factors | Natriuretic Peptide, Brain | Nuclear Proteins | Phenylephrine | Promoter Regions, Genetic | Rats | Recombinant Fusion Proteins | Signal Transduction | Transcription Factors | Transcription, Genetic | Transcriptional Activation | Zinc Fingers

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NHLBI NIH HHS, Id: R01 HL053351

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.