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Distribution of olfactory receptor genes in the human genome.

Nature genetics | Mar 30, 1998

We demonstrate that members of the olfactory receptor (OR) gene family are distributed on all but a few human chromosomes. Through FISH analysis, we show that OR sequences reside at more than 25 locations in the human genome. Their distribution is biased for terminal bands. Flow-sorted chromosomes were used to isolate 87 OR sequences derived from 16 chromosomes. Their sequence-relationships are indicative of the inter- and intrachromosomal duplications responsible for OR family expansion. The human genome has accumulated a striking number of dysfunctional copies: 72% of the sequences are pseudogenes. ORF-containing sequences predominate on chromosomes 7, 16 and 17.

Pubmed ID: 9500546 RIS Download

Mesh terms: Amino Acid Sequence | Base Sequence | Chromosome Mapping | Chromosomes, Human | Chromosomes, Human, Pair 17 | Cloning, Molecular | Conserved Sequence | DNA Primers | Genetic Techniques | Humans | In Situ Hybridization, Fluorescence | Introns | Molecular Sequence Data | Multigene Family | Receptors, Odorant | Sequence Analysis | Sequence Homology, Amino Acid

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HGNC (Data, Gene Annotation)

Olfactory Receptor DataBase (Data, Chemosensory Receptor)

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