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Distribution of olfactory receptor genes in the human genome.

We demonstrate that members of the olfactory receptor (OR) gene family are distributed on all but a few human chromosomes. Through FISH analysis, we show that OR sequences reside at more than 25 locations in the human genome. Their distribution is biased for terminal bands. Flow-sorted chromosomes were used to isolate 87 OR sequences derived from 16 chromosomes. Their sequence-relationships are indicative of the inter- and intrachromosomal duplications responsible for OR family expansion. The human genome has accumulated a striking number of dysfunctional copies: 72% of the sequences are pseudogenes. ORF-containing sequences predominate on chromosomes 7, 16 and 17.

Pubmed ID: 9500546

Authors

  • Rouquier S
  • Taviaux S
  • Trask BJ
  • Brand-Arpon V
  • van den Engh G
  • Demaille J
  • Giorgi D

Journal

Nature genetics

Publication Data

March 30, 1998

Associated Grants

None

Mesh Terms

  • Amino Acid Sequence
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human
  • Chromosomes, Human, Pair 17
  • Cloning, Molecular
  • Conserved Sequence
  • DNA Primers
  • Genetic Techniques
  • Humans
  • In Situ Hybridization, Fluorescence
  • Introns
  • Molecular Sequence Data
  • Multigene Family
  • Receptors, Odorant
  • Sequence Analysis
  • Sequence Homology, Amino Acid