Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Distribution of olfactory receptor genes in the human genome.

Nature genetics | Mar 30, 1998

We demonstrate that members of the olfactory receptor (OR) gene family are distributed on all but a few human chromosomes. Through FISH analysis, we show that OR sequences reside at more than 25 locations in the human genome. Their distribution is biased for terminal bands. Flow-sorted chromosomes were used to isolate 87 OR sequences derived from 16 chromosomes. Their sequence-relationships are indicative of the inter- and intrachromosomal duplications responsible for OR family expansion. The human genome has accumulated a striking number of dysfunctional copies: 72% of the sequences are pseudogenes. ORF-containing sequences predominate on chromosomes 7, 16 and 17.

Pubmed ID: 9500546 RIS Download

Mesh terms: Amino Acid Sequence | Base Sequence | Chromosome Mapping | Chromosomes, Human | Chromosomes, Human, Pair 17 | Cloning, Molecular | Conserved Sequence | DNA Primers | Genetic Techniques | Humans | In Situ Hybridization, Fluorescence | Introns | Molecular Sequence Data | Multigene Family | Receptors, Odorant | Sequence Analysis | Sequence Homology, Amino Acid

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants


HGNC (Data, Gene Annotation)

Olfactory Receptor DataBase (Data, Chemosensory Receptor)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.