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The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA.

Science (New York, N.Y.) | Feb 13, 1998

GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The alpha subunit contains a DNA-binding domain that is a member of the ETS family, whereas the beta subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA was determined at 2. 15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein-protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPalpha ETS domain binds to its core GGA DNA-recognition motif.

Pubmed ID: 9461436 RIS Download

Mesh terms: Amino Acid Sequence | Ankyrins | Crystallography, X-Ray | DNA | DNA-Binding Proteins | Dimerization | GA-Binding Protein Transcription Factor | Hydrogen Bonding | Models, Molecular | Molecular Sequence Data | Protein Conformation | Protein Structure, Secondary | Proto-Oncogene Proteins | Proto-Oncogene Proteins c-ets | Recombinant Proteins | Trans-Activators | Transcription Factors

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