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CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95.

Nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS) is important for N-methyl-D-aspartate (NMDA) receptor-dependent neurotransmitter release, neurotoxicity, and cyclic GMP elevations. The coupling of NMDA receptor-mediated calcium influx and nNOS activation is postulated to be due to a physical coupling of the receptor and the enzyme by an intermediary adaptor protein, PSD95, through a unique PDZ-PDZ domain interaction between PSD95 and nNOS. Here, we report the identification of a novel nNOS-associated protein, CAPON, which is highly enriched in brain and has numerous colocalizations with nNOS. CAPON interacts with the nNOS PDZ domain through its C terminus. CAPON competes with PSD95 for interaction with nNOS, and overexpression of CAPON results in a loss of PSD95/nNOS complexes in transfected cells. CAPON may influence nNOS by regulating its ability to associate with PSD95/NMDA receptor complexes.

Pubmed ID: 9459447


  • Jaffrey SR
  • Snowman AM
  • Eliasson MJ
  • Cohen NA
  • Snyder SH



Publication Data

January 9, 1998

Associated Grants

  • Agency: NIDA NIH HHS, Id: DA00074
  • Agency: NIGMS NIH HHS, Id: GM-07309
  • Agency: NIMH NIH HHS, Id: MH-10341

Mesh Terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Binding, Competitive
  • Brain
  • Carrier Proteins
  • Cloning, Molecular
  • Drug Interactions
  • Guanylate Kinase
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Molecular Sequence Data
  • Nerve Tissue Proteins
  • Neurons
  • Nitric Oxide Synthase
  • Rats
  • Rats, Sprague-Dawley
  • Tissue Distribution