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Interaction of a Golgi-associated kinesin-like protein with Rab6.

Science (New York, N.Y.) | Jan 23, 1998

Rab guanosine triphosphatases regulate vesicular transport and membrane traffic within eukaryotic cells. Here, a kinesin-like protein that interacts with guanosine triphosphate (GTP)-bound forms of Rab6 was identified. This protein, termed Rabkinesin-6, was localized to the Golgi apparatus and shown to play a role in the dynamics of this organelle. The carboxyl-terminal domain of Rabkinesin-6, which contains the Rab6-interacting domain, inhibited the effects of Rab6-GTP on intracellular transport. Thus, a molecular motor is a potential effector of a Rab protein, and coordinated action between members of these two families of proteins could control membrane dynamics and directional vesicular traffic.

Pubmed ID: 9438855 RIS Download

Mesh terms: Adenosine Triphosphatases | Alkaline Phosphatase | Amino Acid Sequence | Biological Transport | Carrier Proteins | Endoplasmic Reticulum | Golgi Apparatus | Guanosine Triphosphate | HeLa Cells | Humans | Kinesin | Microtubules | Molecular Sequence Data | Molecular Weight | rab GTP-Binding Proteins | ras Proteins