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Interaction of a Golgi-associated kinesin-like protein with Rab6.

Rab guanosine triphosphatases regulate vesicular transport and membrane traffic within eukaryotic cells. Here, a kinesin-like protein that interacts with guanosine triphosphate (GTP)-bound forms of Rab6 was identified. This protein, termed Rabkinesin-6, was localized to the Golgi apparatus and shown to play a role in the dynamics of this organelle. The carboxyl-terminal domain of Rabkinesin-6, which contains the Rab6-interacting domain, inhibited the effects of Rab6-GTP on intracellular transport. Thus, a molecular motor is a potential effector of a Rab protein, and coordinated action between members of these two families of proteins could control membrane dynamics and directional vesicular traffic.

Pubmed ID: 9438855

Authors

  • Echard A
  • Jollivet F
  • Martinez O
  • Lacapère JJ
  • Rousselet A
  • Janoueix-Lerosey I
  • Goud B

Journal

Science (New York, N.Y.)

Publication Data

January 23, 1998

Associated Grants

None

Mesh Terms

  • Adenosine Triphosphatases
  • Alkaline Phosphatase
  • Amino Acid Sequence
  • Biological Transport
  • Carrier Proteins
  • Endoplasmic Reticulum
  • Golgi Apparatus
  • Guanosine Triphosphate
  • HeLa Cells
  • Humans
  • Kinesin
  • Microtubules
  • Molecular Sequence Data
  • Molecular Weight
  • rab GTP-Binding Proteins
  • ras Proteins