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Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides.

Cell | Dec 12, 1997

http://www.ncbi.nlm.nih.gov/pubmed/9413988

The effects of pituitary-derived melanocortin peptides are primarily attributed to ACTH-mediated adrenocortical glucocorticoid production. Identification of a widely distributed receptor for ACTH/MSH peptides, the melanocortin-5 receptor (MC5-R), suggested non-steroidally mediated systemic effects of these peptides. Targeted disruption of the MC5-R produced mice with a severe defect in water repulsion and thermoregulation due to decreased production of sebaceous lipids. High levels of MC5-R was found in multiple exocrine tissues, including Harderian, preputial, lacrimal, and sebaceous glands, and was also shown to be required for production and stress-regulated synthesis of porphyrins by the Harderian gland and ACTH/MSH-regulated protein secretion by the lacrimal gland. These data show a requirement for the MC5-R in multiple exocrine glands for the production of numerous products, indicative of a coordinated system for regulation of exocrine gland function by melanocortin peptides.

Pubmed ID: 9413988 RIS Download

Mesh terms: Animals | Body Temperature Regulation | Exocrine Glands | Female | Genomic Library | Harderian Gland | Lacrimal Apparatus | Male | Mice | Mice, Knockout | Mice, Transgenic | Organ Specificity | Penis | Porphyrins | RNA, Messenger | Rats | Receptors, Corticotropin | Receptors, Melanocortin | Sebaceous Glands | Transcription, Genetic | Transfection

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Associated grants

  • Agency: NIAMS NIH HHS, Id: AR42415
  • Agency: NICHD NIH HHS, Id: HD30236

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