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Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides.

The effects of pituitary-derived melanocortin peptides are primarily attributed to ACTH-mediated adrenocortical glucocorticoid production. Identification of a widely distributed receptor for ACTH/MSH peptides, the melanocortin-5 receptor (MC5-R), suggested non-steroidally mediated systemic effects of these peptides. Targeted disruption of the MC5-R produced mice with a severe defect in water repulsion and thermoregulation due to decreased production of sebaceous lipids. High levels of MC5-R was found in multiple exocrine tissues, including Harderian, preputial, lacrimal, and sebaceous glands, and was also shown to be required for production and stress-regulated synthesis of porphyrins by the Harderian gland and ACTH/MSH-regulated protein secretion by the lacrimal gland. These data show a requirement for the MC5-R in multiple exocrine glands for the production of numerous products, indicative of a coordinated system for regulation of exocrine gland function by melanocortin peptides.

Pubmed ID: 9413988


  • Chen W
  • Kelly MA
  • Opitz-Araya X
  • Thomas RE
  • Low MJ
  • Cone RD



Publication Data

December 12, 1997

Associated Grants

  • Agency: NIAMS NIH HHS, Id: AR42415
  • Agency: NICHD NIH HHS, Id: HD30236

Mesh Terms

  • Animals
  • Body Temperature Regulation
  • Exocrine Glands
  • Female
  • Genomic Library
  • Harderian Gland
  • Lacrimal Apparatus
  • Male
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Organ Specificity
  • Penis
  • Porphyrins
  • RNA, Messenger
  • Rats
  • Receptors, Corticotropin
  • Receptors, Melanocortin
  • Sebaceous Glands
  • Transcription, Genetic
  • Transfection