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Myodystrophy, a new myopathy on chromosome 8 of the mouse.

A new recessive mutation, myd, causing a diffuse and progressive myopathy in the mouse is described. Histopathological comparisons with normal littermates showed widely distributed focal lesions in all skeletal muscles of myd/myd. Body and organ weights of affected mice were considerably less than those of normal littermates and the mean lifespan of myodystrophic mice that survived weaning was 17 weeks with a range of 5 to 39 weeks. Myodystrophy is located on chromosome 8; it is linked to Os with about 6 percent and to Eso with about 37 percent recombination.

Pubmed ID: 939913


  • Lane PW
  • Beamer TC
  • Myers DD


The Journal of heredity

Publication Data

September 25, 1976

Associated Grants


Mesh Terms

  • Animals
  • Chromosome Mapping
  • Crosses, Genetic
  • Female
  • Genes
  • Genes, Recessive
  • Genetic Linkage
  • Male
  • Mice
  • Muscular Diseases
  • Mutation
  • Phenotype
  • Pigmentation
  • Rodent Diseases