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BIM1 encodes a microtubule-binding protein in yeast.

A previously uncharacterized yeast gene (YER016w) that we have named BIM1 (binding to microtubules) was obtained from a two-hybrid screen of a yeast cDNA library using as bait the entire coding sequence of TUB1 (encoding alpha-tubulin). Deletion of BIM1 results in a strong bilateral karyogamy defect, hypersensitivity to benomyl, and aberrant spindle behavior, all phenotypes associated with mutations affecting microtubules in yeast, and inviability at extreme temperatures (i.e., >/=37 degrees C or

Pubmed ID: 9398684

Authors

  • Schwartz K
  • Richards K
  • Botstein D

Journal

Molecular biology of the cell

Publication Data

December 28, 1997

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM-46406

Mesh Terms

  • Alleles
  • Amino Acid Sequence
  • Cell Cycle
  • Cell Cycle Proteins
  • Cell Nucleus
  • Cell Size
  • Cytoskeleton
  • Fungal Proteins
  • Genes, Fungal
  • Genes, Lethal
  • Humans
  • Microtubule Proteins
  • Microtubule-Associated Proteins
  • Microtubules
  • Molecular Sequence Data
  • Mutation
  • Nuclear Proteins
  • Phenotype
  • Protein Binding
  • Recombinant Fusion Proteins
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Spindle Apparatus
  • Tubulin
  • Two-Hybrid System Techniques