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BIM1 encodes a microtubule-binding protein in yeast.

A previously uncharacterized yeast gene (YER016w) that we have named BIM1 (binding to microtubules) was obtained from a two-hybrid screen of a yeast cDNA library using as bait the entire coding sequence of TUB1 (encoding alpha-tubulin). Deletion of BIM1 results in a strong bilateral karyogamy defect, hypersensitivity to benomyl, and aberrant spindle behavior, all phenotypes associated with mutations affecting microtubules in yeast, and inviability at extreme temperatures (i.e., >/=37 degrees C or

Pubmed ID: 9398684 RIS Download

Mesh terms: Alleles | Amino Acid Sequence | Cell Cycle | Cell Cycle Proteins | Cell Nucleus | Cell Size | Cytoskeleton | Fungal Proteins | Genes, Fungal | Genes, Lethal | Humans | Microtubule Proteins | Microtubule-Associated Proteins | Microtubules | Molecular Sequence Data | Mutation | Nuclear Proteins | Phenotype | Protein Binding | Recombinant Fusion Proteins | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Spindle Apparatus | Tubulin | Two-Hybrid System Techniques

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Associated grants

  • Agency: NIGMS NIH HHS, Id: R01 GM046406
  • Agency: NIGMS NIH HHS, Id: R37 GM046406
  • Agency: NIGMS NIH HHS, Id: GM-46406

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