The recent identification of the SMAD family of signal transducer proteins has unravelled the mechanisms by which transforming growth factor-beta (TGF-beta) signals from the cell membrane to the nucleus. Pathway-restricted SMADs are phosphorylated by specific cell-surface receptors that have serine/threonine kinase activity, then they oligomerize with the common mediator Smad4 and translocate to the nucleus where they direct transcription to effect the cell's response to TGF-beta. Inhibitory SMADs have been identified that block the activation of these pathway-restricted SMADs.
Pubmed ID: 9393997 RIS Download
Mesh terms: Animals | Cell Membrane | Cell Nucleus | Cell Transformation, Neoplastic | DNA-Binding Proteins | Gene Expression Regulation | Humans | Signal Transduction | Smad1 Protein | Transforming Growth Factor beta
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