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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.

Science (New York, N.Y.) | Nov 28, 1997

http://www.ncbi.nlm.nih.gov/pubmed/9374458

The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-kappaB) activation in mammals and is similar to the Toll pathway in Drosophila: the IL-1R-associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R-induced NF-kappaB activation: IRAK-2, a Pelle family member, and MyD88, a death domain-containing adapter molecule. Both associate with the IL-1R signaling complex. Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation.

Pubmed ID: 9374458 RIS Download

Mesh terms: Adaptor Proteins, Signal Transducing | Amino Acid Sequence | Antigens, Differentiation | Carrier Proteins | Cell Line | Drosophila Proteins | Humans | Interleukin-1 | Interleukin-1 Receptor-Associated Kinases | Molecular Sequence Data | Myeloid Differentiation Factor 88 | NF-kappa B | Protein Kinases | Protein-Serine-Threonine Kinases | Proteins | Receptors, Immunologic | Receptors, Interleukin-1 | Sequence Alignment | Sequence Homology, Amino Acid | Signal Transduction | TNF Receptor-Associated Factor 6 | Transfection

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