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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.

Pubmed ID: 9363890


  • Kuro-o M
  • Matsumura Y
  • Aizawa H
  • Kawaguchi H
  • Suga T
  • Utsugi T
  • Ohyama Y
  • Kurabayashi M
  • Kaname T
  • Kume E
  • Iwasaki H
  • Iida A
  • Shiraki-Iida T
  • Nishikawa S
  • Nagai R
  • Nabeshima YI



Publication Data

November 6, 1997

Associated Grants


Mesh Terms

  • Aging
  • Amino Acid Sequence
  • Animals
  • Arteriosclerosis
  • Atrophy
  • Calcinosis
  • Cloning, Molecular
  • Emphysema
  • Female
  • Genitalia
  • Humans
  • Male
  • Membrane Proteins
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Molecular Sequence Data
  • Mutagenesis, Insertional
  • Osteoporosis
  • Phenotype
  • Pituitary Gland
  • Sequence Homology, Amino Acid
  • Skin
  • Syndrome
  • Thymus Gland