Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
Pubmed ID: 9363890 RIS Download
Aging | Amino Acid Sequence | Animals | Arteriosclerosis | Atrophy | Calcinosis | Cloning, Molecular | Emphysema | Female | Genitalia | Humans | Male | Membrane Proteins | Mice | Mice, Inbred BALB C | Mice, Inbred C3H | Mice, Inbred C57BL | Mice, Transgenic | Molecular Sequence Data | Mutagenesis, Insertional | Osteoporosis | Phenotype | Pituitary Gland | Sequence Homology, Amino Acid | Skin | Syndrome | Thymus Gland