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daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.

The wild-type Caenorhabditis elegans nematode ages rapidly, undergoing development, senescence, and death in less than 3 weeks. In contrast, mutants with reduced activity of the gene daf-2, a homolog of the insulin and insulin-like growth factor receptors, age more slowly than normal and live more than twice as long. These mutants are active and fully fertile and have normal metabolic rates. The life-span extension caused by daf-2 mutations requires the activity of the gene daf-16. daf-16 appears to play a unique role in life-span regulation and encodes a member of the hepatocyte nuclear factor 3 (HNF-3)/forkhead family of transcriptional regulators. In humans, insulin down-regulates the expression of certain genes by antagonizing the activity of HNF-3, raising the possibility that aspects of this regulatory system have been conserved.

Pubmed ID: 9360933

Authors

  • Lin K
  • Dorman JB
  • Rodan A
  • Kenyon C

Journal

Science (New York, N.Y.)

Publication Data

November 14, 1997

Associated Grants

  • Agency: NIA NIH HHS, Id: AG11816

Mesh Terms

  • Aging
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cloning, Molecular
  • DNA, Complementary
  • Forkhead Transcription Factors
  • Genes, Helminth
  • Humans
  • Insulin
  • Longevity
  • Molecular Sequence Data
  • Mutation
  • Nuclear Proteins
  • Phenotype
  • Receptor, Insulin
  • Sequence Alignment
  • Somatomedins
  • Transcription Factors