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daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.

Science (New York, N.Y.) | Nov 14, 1997

http://www.ncbi.nlm.nih.gov/pubmed/9360933

The wild-type Caenorhabditis elegans nematode ages rapidly, undergoing development, senescence, and death in less than 3 weeks. In contrast, mutants with reduced activity of the gene daf-2, a homolog of the insulin and insulin-like growth factor receptors, age more slowly than normal and live more than twice as long. These mutants are active and fully fertile and have normal metabolic rates. The life-span extension caused by daf-2 mutations requires the activity of the gene daf-16. daf-16 appears to play a unique role in life-span regulation and encodes a member of the hepatocyte nuclear factor 3 (HNF-3)/forkhead family of transcriptional regulators. In humans, insulin down-regulates the expression of certain genes by antagonizing the activity of HNF-3, raising the possibility that aspects of this regulatory system have been conserved.

Pubmed ID: 9360933 RIS Download

Mesh terms: Aging | Amino Acid Sequence | Animals | Base Sequence | Caenorhabditis elegans | Caenorhabditis elegans Proteins | Cloning, Molecular | DNA, Complementary | Forkhead Transcription Factors | Genes, Helminth | Humans | Insulin | Longevity | Molecular Sequence Data | Mutation | Nuclear Proteins | Phenotype | Receptor, Insulin | Sequence Alignment | Somatomedins | Transcription Factors