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Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease.

Science (New York, N.Y.) | Oct 31, 1997

http://www.ncbi.nlm.nih.gov/pubmed/9346488

To create mice expressing exclusively human sickle hemoglobin (HbS), transgenic mice expressing human alpha-, gamma-, and betaS-globin were generated and bred with knockout mice that had deletions of the murine alpha- and beta-globin genes. These sickle cell mice have the major features (irreversibly sickled red cells, anemia, multiorgan pathology) found in humans with sickle cell disease and, as such, represent a useful in vivo system to accelerate the development of improved therapies for this common genetic disease.

Pubmed ID: 9346488 RIS Download

Mesh terms: Anemia, Sickle Cell | Animals | Disease Models, Animal | Female | Globins | Hemoglobin, Sickle | Humans | Male | Mice | Mice, Inbred C57BL | Mice, Knockout | Mice, Transgenic

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Associated grants

  • Agency: NHLBI NIH HHS, Id: HL20985
  • Agency: NHLBI NIH HHS, Id: HL31579
  • Agency: NHLBI NIH HHS, Id: N01-HB-07086

Mouse Genome Informatics (Data, Gene Annotation)

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